dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000812
Uniprot Accession O14979; HNRDL_HUMAN; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43;
Genbank Protein ID NP_001193929.1; NP_112740.1;
Genbank Nucleotide ID NM_001207000.1; NM_031372.3;
Protein Name Heterogeneous nuclear ribonucleoprotein D-like
Protein Synonyms/Alias
Gene Name HNRNPDL
Gene Synonyms/Alias HNRPDL;JKTBP;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.
Phosphorylation Sites
 dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
24SAPATLASRSLSHWRdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
94RRHFKSSSIQRSAAAPhosphoSitePlus;curated22135298; 22817900
98KSSSIQRSAAAAAATPhosphoSitePlus;curated22135298; 22817900
126TMEDMNEYSNIEEFAdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18452278; 16381945; 23193290; 18988627; 22135298; 22817900;
127MEDMNEYSNIEEFAEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19651622; 16381945; 23193290; 18988627; 22135298; 25627689;
136IEEFAEGSKINASKNPhosphoSitePlus22135298
156KMFIGGLSWDTSKKDPhosphoSitePlus22135298
165DTSKKDLTEYLSRFGPhosphoSitePlus22135298
167SKKDLTEYLSRFGEVcurated22817900
169KDLTEYLSRFGEVVDPhosphoSitePlus22135298
178FGEVVDCTIKTDPVTPhosphoSitePlus;curated22135298; 24667141
241KVFVGGLSPDTSEEQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 19413330; 19690332; 16381945; 23193290; 15302935;
244VGGLSPDTSEEQIKEcurated25627689
245GGLSPDTSEEQIKEYcurated25627689
295KKLLESRYHQIGSGKdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
300SRYHQIGSGKCEIKVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
314VAQPKEVYRQQQQQQdbPTM 3.0;PhosphoSitePlus;curated18083107; 19702290; 16381945; 23193290; 22135298; 22817900;
387TGYNYGNYGYGQGYAPhosphoSitePlus22135298
389YNYGNYGYGQGYADYPhosphoSitePlus22135298
396YGQGYADYSGQQSTYPhosphoSitePlus22135298
Sequence
(Fasta)		MEVPPRLSHV PPPLFPSAPA TLASRSLSHW RPRPPRQLAP LLPSLAPSSA RQGARRAQRH 60
VTAQQPSRLA GGAAIKGGRR RRPDLFRRHF KSSSIQRSAA AAAATRTARQ HPPADSSVTM 120
EDMNEYSNIE EFAEGSKINA SKNQQDDGKM FIGGLSWDTS KKDLTEYLSR FGEVVDCTIK 180
TDPVTGRSRG FGFVLFKDAA SVDKVLELKE HKLDGKLIDP KRAKALKGKE PPKKVFVGGL 240
SPDTSEEQIK EYFGAFGEIE NIELPMDTKT NERRGFCFIT YTDEEPVKKL LESRYHQIGS 300
GKCEIKVAQP KEVYRQQQQQ QKGGRGAAAG GRGGTRGRGR GQGQNWNQGF NNYYDQGYGN 360
YNSAYGGDQN YSGYGGYDYT GYNYGNYGYG QGYADYSGQQ STYGKASRGG GNHQNNYQPY 420
421
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0947--Limb-girdle muscular dystrophy
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0694--RNA-binding
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
PROSITE

PS50102--RRM
Pfam

PF00076--RRM_1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0003677--F:DNA binding
GO:0003690--F:double-stranded DNA binding
GO:0000166--F:nucleotide binding
GO:0008143--F:poly(A) binding
GO:0044822--F:poly(A) RNA binding
GO:0034046--F:poly(G) binding
GO:0003697--F:single-stranded DNA binding
GO:0010468--P:regulation of gene expression
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006396--P:RNA processing
GO:0006351--P:transcription, DNA-templated