dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000810
Uniprot Accession O14976; GAK_HUMAN; Q5U4P5; Q9BVY6;
Genbank Protein ID NP_001273762.1; NP_005246.2; XP_011511735.1;
Genbank Nucleotide ID NM_001286833.1; NM_005255.2; XM_011513433.1;
Protein Name Cyclin-G-associated kinase
Protein Synonyms/Alias
Gene Name GAK
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
Phosphorylation Sites
 dbPAF PTMs: 59 (View all)
PositionPeptidesSourceReferences ( PMIDs )
2------MSLLQSALDcurated20873877
16DFLAGPGSLGGASGRdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 19369195; 16381945; 23193290; 18988627; 21081558;
21PGSLGGASGRDQSDFcurated20873877
73YALKRLLSNEEEKNRPhosphoSitePlus;curated22135298; 25627689; 20873877; 22817900
112ASIGKEESDTGQAEFPhosphoPep 2.019060867
114IGKEESDTGQAEFLLPhosphoPep 2.019060867
153DTVLKIFYQTCRAVQPhosphoSitePlus22135298
201SATTISHYPDYSWSAPhosphoSitePlus22135298
204TISHYPDYSWSAQRRdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
207HYPDYSWSAQRRALVPhosphoPep 2.019060867
235TPEIIDLYSNFPIGEPhosphoSitePlus22135298
276LRIVNGKYSIPPHDTPhosphoSitePlus22135298
277RIVNGKYSIPPHDTQPhosphoSitePlus22135298
285IPPHDTQYTVFHSLIPhosphoSitePlus22135298
290TQYTVFHSLIRAMLQPhosphoSitePlus22135298
326ARNVNPKSPITELLEdbPTM 3.0;PhosphoPep 2.0;curated19369195; 16381945; 23193290; 19060867
338LLEQNGGYGSATLSRPhosphoSitePlus22135298
340EQNGGYGSATLSRGPPhosphoSitePlus22135298
367GGLALAEYDQPYGGFPhosphoSitePlus22135298
371LAEYDQPYGGFLDILdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDV 60
GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120
LLTELCKGQL VEFLKKMESR GPLSCDTVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL 180
LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR NTTPMYRTPE IIDLYSNFPI 240
GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP HDTQYTVFHS LIRAMLQVNP 300
EERLSIAEVV HQLQEIAAAR NVNPKSPITE LLEQNGGYGS ATLSRGPPPP VGPAGSGYSG 360
GLALAEYDQP YGGFLDILRG GTERLFTNLK DTSSKVIQSV ANYAKGDLDI SYITSRIAVM 420
SFPAEGVESA LKNNIEDVRL FLDSKHPGHY AVYNLSPRTY RPSRFHNRVS ECGWAARRAP 480
HLHTLYNICR NMHAWLRQDH KNVCVVHCMD GRAASAVAVC SFLCFCRLFS TAEAAVYMFS 540
MKRCPPGIWP SHKRYIEYMC DMVAEEPITP HSKPILVRAV VMTPVPLFSK QRSGCRPFCE 600
VYVGDERVAS TSQEYDKMRD FKIEDGKAVI PLGVTVQGDV LIVIYHARST LGGRLQAKMA 660
SMKMFQIQFH TGFVPRNATT VKFAKYDLDA CDIQEKYPDL FQVNLEVEVE PRDRPSREAP 720
PWENSSMRGL NPKILFSSRE EQQDILSKFG KPELPRQPGS TAQYDAGAGS PEAEPTDSDS 780
PPSSSADASR FLHTLDWQEE KEAETGAENA SSKESESALM EDRDESEVSD EGGSPISSEG 840
QEPRADPEPP GLAAGLVQQD LVFEVETPAV LPEPVPQEDG VDLLGLHSEV GAGPAVPPQA 900
CKAPSSNTDL LSCLLGPPEA ASQGPPEDLL SEDPLLLASP APPLSVQSTP RGGPPAAADP 960
FGPLLPSSGN NSQPCSNPDL FGEFLNSDSV TVPPSFPSAH SAPPPSCSAD FLHLGDLPGE 1020
PSKMTASSSN PDLLGGWAAW TETAASAVAP TPATEGPLFS PGGQPAPCGS QASWTKSQNP 1080
DPFADLGDLS SGLQGSPAGF PPGGFIPKTA TTPKGSSSWQ TSRPPAQGAS WPPQAKPPPK 1140
ACTQPRPNYA SNFSVIGARE ERGVRAPSFA QKPKVSENDF EDLLSNQGFS SRSDKKGPKT 1200
IAEMRKQDLA KDTDPLKLKL LDWIEGKERN IRALLSTLHT VLWDGESRWT PVGMADLVAP 1260
EQVKKHYRRA VLAVHPDKAA GQPYEQHAKM IFMELNDAWS EFENQGSRPL F 1312
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR000008--C2_dom
IPR001623--DnaJ_domain
IPR011009--Kinase-like_dom
IPR029021--Prot-tyrosine_phosphatase-like
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR014020--Tensin_C2-dom
IPR029023--Tensin_lipid_phosphatase_dom
PROSITE

PS51182--C2_TENSIN
PS50076--DNAJ_2
PS51181--PPASE_TENSIN
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00226--DnaJ
PF00069--Pkinase
PF10409--PTEN_C2
Gene Ontology

GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0007049--P:cell cycle
GO:0007030--P:Golgi organization
GO:0010977--P:negative regulation of neuron projection development