dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000809
Uniprot Accession O14975; S27A2_HUMAN; A8K2J7; Q53FY6; Q6PF09;
Genbank Protein ID NP_001153101.1; NP_003636.2;
Genbank Nucleotide ID NM_001159629.1; NM_003645.3;
Protein Name Very long-chain acyl-CoA synthetase
Protein Synonyms/Alias
Gene Name SLC27A2
Gene Synonyms/Alias ACSVL1;FACVL1;FATP2;VLACS;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
158GAKVLLVSPELQAAVPhosphoSitePlus22135298
238LPKAAMITHQRIWYGdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
244ITHQRIWYGTGLTFVdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
249IWYGTGLTFVSGLKAdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
252GTGLTFVSGLKADDVdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 22817900
304FWDDCRKYNVTVIQYPhosphoSitePlus22135298
322LLRYLCNSPQKPNDRcurated20873877
393YLQKKIITYDLIKYDPhosphoSitePlus22135298
528EGRIGMASIKMKENHPhosphoSitePlus22135298
577TFKHRKMTLVEEGFNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 20068231; 20166139; 20736484;
602LDDTAKMYVPMTEDIPhosphoSitePlus22135298
610VPMTEDIYNAISAKTPhosphoSitePlus22135298
Sequence
(Fasta)		MLSAIYTVLA GLLFLPLLVN LCCPYFFQDI GYFLKVAAVG RRVRSYGKRR PARTILRAFL 60
EKARQTPHKP FLLFRDETLT YAQVDRRSNQ VARALHDHLG LRQGDCVALL MGNEPAYVWL 120
WLGLVKLGCA MACLNYNIRA KSLLHCFQCC GAKVLLVSPE LQAAVEEILP SLKKDDVSIY 180
YVSRTSNTDG IDSFLDKVDE VSTEPIPESW RSEVTFSTPA LYIYTSGTTG LPKAAMITHQ 240
RIWYGTGLTF VSGLKADDVI YITLPFYHSA ALLIGIHGCI VAGATLALRT KFSASQFWDD 300
CRKYNVTVIQ YIGELLRYLC NSPQKPNDRD HKVRLALGNG LRGDVWRQFV KRFGDICIYE 360
FYAATEGNIG FMNYARKVGA VGRVNYLQKK IITYDLIKYD VEKDEPVRDE NGYCVRVPKG 420
EVGLLVCKIT QLTPFNGYAG AKAQTEKKKL RDVFKKGDLY FNSGDLLMVD HENFIYFHDR 480
VGDTFRWKGE NVATTEVADT VGLVDFVQEV NVYGVHVPDH EGRIGMASIK MKENHEFDGK 540
KLFQHIADYL PSYARPRFLR IQDTIEITGT FKHRKMTLVE EGFNPAVIKD ALYFLDDTAK 600
MYVPMTEDIY NAISAKTLKL 621
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0276--Fatty acid metabolism
KW-0436--Ligase
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0576--Peroxisome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR025110--AMP-bd_C
IPR020845--AMP-binding_CS
IPR000873--AMP-dep_Synth/Lig
IPR030305--FATP2
PROSITE

PS00455--AMP_BINDING
Pfam

PF00501--AMP-binding
PF13193--AMP-binding_C
Gene Ontology

GO:0005788--C:endoplasmic reticulum lumen
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0005779--C:integral component of peroxisomal membrane
GO:0005739--C:mitochondrion
GO:0005778--C:peroxisomal membrane
GO:0005524--F:ATP binding
GO:0019899--F:enzyme binding
GO:0015245--F:fatty acid transporter activity
GO:0004467--F:long-chain fatty acid-CoA ligase activity
GO:0050197--F:phytanate-CoA ligase activity
GO:0070251--F:pristanate-CoA ligase activity
GO:0005102--F:receptor binding
GO:0031957--F:very long-chain fatty acid-CoA ligase activity
GO:0006699--P:bile acid biosynthetic process
GO:0008206--P:bile acid metabolic process
GO:0044255--P:cellular lipid metabolic process
GO:0001561--P:fatty acid alpha-oxidation
GO:0006635--P:fatty acid beta-oxidation
GO:0044539--P:long-chain fatty acid import
GO:0001676--P:long-chain fatty acid metabolic process
GO:0097089--P:methyl-branched fatty acid metabolic process
GO:0044281--P:small molecule metabolic process
GO:0042760--P:very long-chain fatty acid catabolic process