dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000808
Uniprot Accession O14974; MYPT1_HUMAN; B4DZ09; F8VWB4; Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0;
Genbank Protein ID NP_001137357.1; NP_001137358.1; NP_001231919.1; NP_001231921.1; NP_002471.1; XP_011536685.1;
Genbank Nucleotide ID NM_001143885.1; NM_001143886.1; NM_001244990.1; NM_001244992.1; NM_002480.2; XM_011538383.1;
Protein Name Protein phosphatase 1 regulatory subunit 12A
Protein Synonyms/Alias Myosin phosphatase-targeting subunit 1;Myosin phosphatase target subunit 1;Protein phosphatase myosin-binding subunit;
Gene Name PPP1R12A
Gene Synonyms/Alias MBS;MYPT1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.
Phosphorylation Sites
 dbPAF PTMs: 138 (View all)
PositionPeptidesSourceReferences ( PMIDs )
20QLKRWIGSETDLEPPdbPTM 3.0;PhosphoSitePlus22516431; 16381945; 23193290; 22135298
22KRWIGSETDLEPPVVdbPTM 3.0;PhosphoSitePlus22516431; 16381945; 23193290; 22135298
49AVFLAACSSGDTDEVPhosphoSitePlus22135298
68HRGADINYANVDGLTPhosphoSitePlus22135298
198NDVRHAKSGGTALHVdbPTM 3.0;HPRD 9;PHOSIDA;curated20068231; 16381945; 23193290; 18988627; 21081558
292KKQNLLHSEKRDKKSPhosphoSitePlus;curated22135298; 25627689
299SEKRDKKSPLIESTAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 17446864; 19664994; 20068231;
304KKSPLIESTANMDNNdbPTM 3.0;PhosphoSitePlus;curated20044836; 22516431; 16381945; 23193290; 22135298; 25850435;
305KSPLIESTANMDNNQdbPTM 3.0;HPRD 9;curated18767875; 16381945; 23193290; 18988627; 25849741
313ANMDNNQSQKTFKNKPhosphoSitePlus;curated22135298; 24961811
336KNASRIESLEQEKVDPhosphoSitePlus;curated22135298; 25627689; 23090842
374SEAETDKTKPLASVTcurated23090842
379DKTKPLASVTNANTScurated23090842; 22199227
381TKPLASVTNANTSSTcurated23090842
385ASVTNANTSSTQAAPcurated23090842
386SVTNANTSSTQAAPVcurated25627689
388TNANTSSTQAAPVAVcurated23090842
396QAAPVAVTTPTVSSGcurated23090842
397AAPVAVTTPTVSSGQcurated23090842
399PVAVTTPTVSSGQATcurated25627689; 23090842
Sequence
(Fasta)		MKMADAKQKR NEQLKRWIGS ETDLEPPVVK RQKTKVKFDD GAVFLAACSS GDTDEVLKLL 60
HRGADINYAN VDGLTALHQA CIDDNVDMVK FLVENGANIN QPDNEGWIPL HAAASCGYLD 120
IAEFLIGQGA HVGAVNSEGD TPLDIAEEEA MEELLQNEVN RQGVDIEAAR KEEERIMLRD 180
ARQWLNSGHI NDVRHAKSGG TALHVAAAKG YTEVLKLLIQ AGYDVNIKDY DGWTPLHAAA 240
HWGKEEACRI LVDNLCDMEM VNKVGQTAFD VADEDILGYL EELQKKQNLL HSEKRDKKSP 300
LIESTANMDN NQSQKTFKNK ETLIIEPEKN ASRIESLEQE KVDEEEEGKK DESSCSSEED 360
EEDDSESEAE TDKTKPLASV TNANTSSTQA APVAVTTPTV SSGQATPTSP IKKFPTTATK 420
ISPKEEERKD ESPATWRLGL RKTGSYGALA EITASKEGQK EKDTAGVTRS ASSPRLSSSL 480
DNKEKEKDSK GTRLAYVAPT IPRRLASTSD IEEKENRDSS SLRTSSSYTR RKWEDDLKKN 540
SSVNEGSTYH KSCSFGRRQD DLISSSVPST TSTPTVTSAA GLQKSLLSST STTTKITTGS 600
SSAGTQSSTS NRLWAEDSTE KEKDSVPTAV TIPVAPTVVN AAASTTTLTT TTAGTVSSTT 660
EVRERRRSYL TPVRDEESES QRKARSRQAR QSRRSTQGVT LTDLQEAEKT IGRSRSTRTR 720
EQENEEKEKE EKEKQDKEKQ EEKKESETSR EDEYKQKYSR TYDETYQRYR PVSTSSSTTP 780
SSSLSTMSSS LYASSQLNRP NSLVGITSAY SRGITKENER EGEKREEEKE GEDKSQPKSI 840
RERRRPREKR RSTGVSFWTQ DSDENEQEQQ SDTEEGSNKK ETQTDSISRY ETSSTSAGDR 900
YDSLLGRSGS YSYLEERKPY SSRLEKDDST DFKKLYEQIL AENEKLKAQL HDTNMELTDL 960
KLQLEKATQR QERFADRSLL EMEKRERRAL ERRISEMEEE LKMLPDLKAD NQRLKDENGA 1020
LIRVISKLSK 1031
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0379--Hydroxylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR017401--MYPT1/MYPT2_chordates
IPR031775--PRKG1_interact
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
Pfam

PF15898--PRKG1_interact
Gene Ontology

GO:0031672--C:A band
GO:0015629--C:actin cytoskeleton
GO:0005813--C:centrosome
GO:0043292--C:contractile fiber
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0000776--C:kinetochore
GO:0005654--C:nucleoplasm
GO:0072357--C:PTW/PP1 phosphatase complex
GO:0030018--C:Z disc
GO:0071889--F:14-3-3 protein binding
GO:0004857--F:enzyme inhibitor activity
GO:0019208--F:phosphatase regulator activity
GO:0019901--F:protein kinase binding
GO:0004871--F:signal transducer activity
GO:0051297--P:centrosome organization
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0000278--P:mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0043086--P:negative regulation of catalytic activity
GO:0035508--P:positive regulation of myosin-light-chain-phosphatase activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006470--P:protein dephosphorylation
GO:0030155--P:regulation of cell adhesion
GO:0035507--P:regulation of myosin-light-chain-phosphatase activity
GO:0046822--P:regulation of nucleocytoplasmic transport
GO:0007264--P:small GTPase mediated signal transduction