dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000806
Uniprot Accession O14967; CLGN_HUMAN; B3KS90; B4DXV8; D3DNY8;
Genbank Protein ID NP_001124147.1; NP_004353.1;
Genbank Nucleotide ID NM_001130675.1; NM_004362.2;
Protein Name Calmegin
Protein Synonyms/Alias
Gene Name CLGN
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
554MLEKEEESEPEEKSEdbPTM 3.0;PhosphoSitePlus;curated20363803; 21406692; 16381945; 23193290; 22135298; 22817900;
560ESEPEEKSEEEIEIIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 20363803; 18988627; 21081558;
576GQEESNQSNKSGSEDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 18988627; 21081558; 19366988;
579ESNQSNKSGSEDEMKcurated22798277; 25849741; 24972180
581NQSNKSGSEDEMKEAPhosphoSitePlus;curated22135298; 23911959; 25849741
591EMKEADESTGSGDGPPhosphoSitePlus;curated22135298; 25627689
592MKEADESTGSGDGPIcurated25627689
594EADESTGSGDGPIKSPhosphoSitePlus;curated22135298; 25627689; 22817900; 20363803
601SGDGPIKSVRKRRVRdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 20363803; 21406692; 16381945; 23193290; 18988627;
Sequence
(Fasta)		MHFQAFWLCL GLLFISINAE FMDDDVETED FEENSEEIDV NESELSSEIK YKTPQPIGEV 60
YFAETFDSGR LAGWVLSKAK KDDMDEEISI YDGRWEIEEL KENQVPGDRG LVLKSRAKHH 120
AISAVLAKPF IFADKPLIVQ YEVNFQDGID CGGAYIKLLA DTDDLILENF YDKTSYIIMF 180
GPDKCGEDYK LHFIFRHKHP KTGVFEEKHA KPPDVDLKKF FTDRKTHLYT LVMNPDDTFE 240
VLVDQTVVNK GSLLEDVVPP IKPPKEIEDP NDKKPEEWDE RAKIPDPSAV KPEDWDESEP 300
AQIEDSSVVK PAGWLDDEPK FIPDPNAEKP DDWNEDTDGE WEAPQILNPA CRIGCGEWKP 360
PMIDNPKYKG VWRPPLVDNP NYQGIWSPRK IPNPDYFEDD HPFLLTSFSA LGLELWSMTS 420
DIYFDNFIIC SEKEVADHWA ADGWRWKIMI ANANKPGVLK QLMAAAEGHP WLWLIYLVTA 480
GVPIALITSF CWPRKVKKKH KDTEYKKTDI CIPQTKGVLE QEEKEEKAAL EKPMDLEEEK 540
KQNDGEMLEK EEESEPEEKS EEEIEIIEGQ EESNQSNKSG SEDEMKEADE STGSGDGPIK 600
SVRKRRVRKD 611
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0143--Chaperone
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001580--Calret/calnex
IPR018124--Calret/calnex_CS
IPR009033--Calreticulin/calnexin_P_dom
IPR013320--ConA-like_dom
PROSITE

PS00803--CALRETICULIN_1
PS00804--CALRETICULIN_2
PS00805--CALRETICULIN_REPEAT
Pfam

PF00262--Calreticulin
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005635--C:nuclear envelope
GO:0005509--F:calcium ion binding
GO:0051082--F:unfolded protein binding
GO:0007339--P:binding of sperm to zona pellucida
GO:0006461--P:protein complex assembly
GO:0006457--P:protein folding
GO:0007338--P:single fertilization