dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000805
Uniprot Accession O14966; RAB7L_HUMAN; B4E1K3; C9JE77;
Genbank Protein ID NP_001129134.1; NP_001129135.1; NP_001129136.1; NP_003920.1; XP_005245626.1; XP_005245627.1; XP_005245628.1; XP_006711668.1; XP_006711669.1; XP_011508398.1;
Genbank Nucleotide ID NM_001135662.1; NM_001135663.1; NM_001135664.1; NM_003929.2; XM_005245569.1; XM_005245570.1; XM_005245571.1; XM_006711605.2; XM_006711606.1; XM_011510096.1;
Protein Name Ras-related protein Rab-7L1
Protein Synonyms/Alias Rab-7-like protein 1;Ras-related protein Rab-29;
Gene Name RAB29
Gene Synonyms/Alias RAB7L1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
31VQRYSQDSFSKHYKSPhosphoSitePlus22135298
38SFSKHYKSTVGVDFAPhosphoSitePlus22135298
39FSKHYKSTVGVDFALPhosphoSitePlus22135298
54KVLQWSDYEIVRLQLPhosphoSitePlus22135298
130LANKCDLSPWAVSRDPhosphoSitePlus22135298
149FSKENGFTGWTETSVPhosphoSitePlus22135298
154GFTGWTETSVKENKNPhosphoSitePlus22135298
155FTGWTETSVKENKNIPhosphoSitePlus22135298
183NSTEDIMSLSTQGDYcurated25627689
185TEDIMSLSTQGDYINdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18988627; 22135298; 25627689;
186EDIMSLSTQGDYINLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;curated18669648; 16381945; 23193290; 20068231; 18988627; 21081558;
190SLSTQGDYINLQTKSdbPTM 3.0;PhosphoSitePlus;curated20562096; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MGSRDHLFKV LVVGDAAVGK TSLVQRYSQD SFSKHYKSTV GVDFALKVLQ WSDYEIVRLQ 60
LWDIAGQERF TSMTRLYYRD ASACVIMFDV TNATTFSNSQ RWKQDLDSKL TLPNGEPVPC 120
LLLANKCDLS PWAVSRDQID RFSKENGFTG WTETSVKENK NINEAMRVLI EKMMRNSTED 180
IMSLSTQGDY INLQTKSSSW SCC 204
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0221--Differentiation
KW-0333--Golgi apparatus
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0636--Prenylation
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0926--Vacuole
Interpro

IPR027417--P-loop_NTPase
IPR030697--Rab29
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR003579--Small_GTPase_Rab_type
PROSITE

PS51419--RAB
Pfam

PF00071--Ras
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0042470--C:melanosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005802--C:trans-Golgi network
GO:0005773--C:vacuole
GO:0019003--F:GDP binding
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0007030--P:Golgi organization
GO:0006895--P:Golgi to endosome transport
GO:0006886--P:intracellular protein transport
GO:0032438--P:melanosome organization
GO:0010977--P:negative regulation of neuron projection development
GO:0090316--P:positive regulation of intracellular protein transport
GO:0032482--P:Rab protein signal transduction
GO:0035526--P:retrograde transport, plasma membrane to Golgi