dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000804
Uniprot Accession O14965; AURKA_HUMAN; E1P5F9; O60445; O75873; Q9BQD6; Q9UPG5;
Genbank Protein ID NP_003591.2; NP_940835.1; NP_940836.1; NP_940837.1; NP_940838.1; NP_940839.1; XP_005260591.1; XP_006723935.1;
Genbank Nucleotide ID NM_003600.2; NM_198433.1; NM_198434.1; NM_198435.1; NM_198436.1; NM_198437.1; XM_005260534.1; XM_006723872.1;
Protein Name Aurora kinase A
Protein Synonyms/Alias Aurora 2;Aurora/IPL1-related kinase 1;ARK-1;Aurora-related kinase 1;hARK1;Breast tumor-amplified kinase;Serine/threonine-protein kinase 15;Serine/threonine-protein kinase 6;Serine/threonine-protein kinase aurora-A;
Gene Name AURKA
Gene Synonyms/Alias AIK;AIRK1;ARK1;AURA;AYK1;BTAK;IAK1;STK15;STK6;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Phosphorylation Sites
 dbPAF PTMs: 29 (View all)
PositionPeptidesSourceReferences ( PMIDs )
4----MDRSKENCISGdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18691976; 16381945; 23193290; 18988627; 22135298
10RSKENCISGPVKATAdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16083426; 16381945; 23193290; 22135298; 22817900
16ISGPVKATAPVGGPKdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16083426; 16381945; 23193290; 22135298; 22817900
41QNPLPVNSGQAQRVLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 16381945; 23193290; 16083426; 18988627; 21081558;
51AQRVLCPSNSSQRVPdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17229885; 18691976; 19007248; 16381945; 23193290; 17895985;
53RVLCPSNSSQRVPLQdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated19369195; 16381945; 23193290; 18691976; 19060867; 22135298
54VLCPSNSSQRVPLQAPhosphoSitePlus22135298
66LQAQKLVSSHKPVQNdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18691976; 16381945; 23193290; 18988627; 22135298; 25627689;
67QAQKLVSSHKPVQNQdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16083426; 16381945; 23193290; 22135298; 25627689; 22817900
83QKQLQATSVPHPVSRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 16083426; 18988627; 21081558;
89TSVPHPVSRPLNNTQdbPTM 3.0;PhosphoSitePlus22451695; 16381945; 23193290; 22135298
98PLNNTQKSKQPLPSAdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16083426; 16381945; 23193290; 22135298; 22817900
104KSKQPLPSAPENNPEdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16083426; 16381945; 23193290; 22135298; 22817900
116NPEEELASKQKNEESdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
148KGKFGNVYLAREKQSdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated16083426; 16381945; 23193290; 18691976; 21081558; 19060867;
197HPNILRLYGYFHDATdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
199NILRLYGYFHDATRVdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
212RVYLILEYAPLGTVYdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
226YRELQKLSKFDEQRTdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16083426; 16381945; 23193290; 22135298; 22817900
266PENLLLGSAGELKIAdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16083426; 16381945; 23193290; 22135298; 20873877; 22817900
Sequence
(Fasta)		MDRSKENCIS GPVKATAPVG GPKRVLVTQQ FPCQNPLPVN SGQAQRVLCP SNSSQRVPLQ 60
AQKLVSSHKP VQNQKQKQLQ ATSVPHPVSR PLNNTQKSKQ PLPSAPENNP EEELASKQKN 120
EESKKRQWAL EDFEIGRPLG KGKFGNVYLA REKQSKFILA LKVLFKAQLE KAGVEHQLRR 180
EVEIQSHLRH PNILRLYGYF HDATRVYLIL EYAPLGTVYR ELQKLSKFDE QRTATYITEL 240
ANALSYCHSK RVIHRDIKPE NLLLGSAGEL KIADFGWSVH APSSRRTTLC GTLDYLPPEM 300
IEGRMHDEKV DLWSLGVLCY EFLVGKPPFE ANTYQETYKR ISRVEFTFPD FVTEGARDLI 360
SRLLKHNPSQ RPMLREVLEH PWITANSSKP SNCQNKESAS KQS 404
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0969--Cilium
KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0493--Microtubule
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation
Interpro

IPR030616--Aur
IPR030611--AURKA
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00069--Pkinase
Gene Ontology

GO:0043203--C:axon hillock
GO:0005813--C:centrosome
GO:0032133--C:chromosome passenger complex
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0005829--C:cytosol
GO:0042585--C:germinal vesicle
GO:0072687--C:meiotic spindle
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0030496--C:midbody
GO:0072686--C:mitotic spindle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0045120--C:pronucleus
GO:0005819--C:spindle
GO:0051233--C:spindle midzone
GO:0031616--C:spindle pole centrosome
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0004672--F:protein kinase activity
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0031145--P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0009948--P:anterior/posterior axis specification
GO:0051301--P:cell division
GO:0051642--P:centrosome localization
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0000278--P:mitotic cell cycle
GO:0007100--P:mitotic centrosome separation
GO:0007067--P:mitotic nuclear division
GO:0007052--P:mitotic spindle organization
GO:0043066--P:negative regulation of apoptotic process
GO:0032091--P:negative regulation of protein binding
GO:1990138--P:neuron projection extension
GO:0045840--P:positive regulation of mitotic nuclear division
GO:1900195--P:positive regulation of oocyte maturation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0046777--P:protein autophosphorylation
GO:0071539--P:protein localization to centrosome
GO:0006468--P:protein phosphorylation
GO:0046605--P:regulation of centrosome cycle
GO:0032465--P:regulation of cytokinesis
GO:0031647--P:regulation of protein stability
GO:0032355--P:response to estradiol
GO:0007057--P:spindle assembly involved in female meiosis I
GO:0043146--P:spindle stabilization