dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000802
Uniprot Accession O14958; CASQ2_HUMAN; B2R7M6; B4DIB0; Q5T1D2; Q8TBW8;
Genbank Protein ID NP_001223.2;
Genbank Nucleotide ID NM_001232.3;
Protein Name Calsequestrin-2
Protein Synonyms/Alias Calsequestrin, cardiac muscle isoform;
Gene Name CASQ2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
36DGKDRVVSLSEKNFKPhosphoSitePlus22135298
176GFFKSEDSEYYKAFEPhosphoSitePlus22135298
178FKSEDSEYYKAFEEAPhosphoSitePlus22135298
179KSEDSEYYKAFEEAAPhosphoSitePlus22135298
282EKSDPDGYEFLEILKPhosphoSitePlus22135298
302NTDNPDLSILWIDPDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;curated18669648; 16381945; 23193290; 18988627; 22817900
385DDDDDDNSDEEDNDDdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt21416293; 16381945; 23193290; 1985907; 18988627; 22135298
393DEEDNDDSDDDDDE-dbPTM 3.0;PhosphoSitePlus;UniProt21416293; 16381945; 23193290; 22135298
Sequence
(Fasta)		MKRTHLFIVG IYFLSSCRAE EGLNFPTYDG KDRVVSLSEK NFKQVLKKYD LLCLYYHEPV 60
SSDKVTQKQF QLKEIVLELV AQVLEHKAIG FVMVDAKKEA KLAKKLGFDE EGSLYILKGD 120
RTIEFDGEFA ADVLVEFLLD LIEDPVEIIS SKLEVQAFER IEDYIKLIGF FKSEDSEYYK 180
AFEEAAEHFQ PYIKFFATFD KGVAKKLSLK MNEVDFYEPF MDEPIAIPNK PYTEEELVEF 240
VKEHQRPTLR RLRPEEMFET WEDDLNGIHI VAFAEKSDPD GYEFLEILKQ VARDNTDNPD 300
LSILWIDPDD FPLLVAYWEK TFKIDLFRPQ IGVVNVTDAD SVWMEIPDDD DLPTAEELED 360
WIEDVLSGKI NTEDDDEDDD DDDNSDEEDN DDSDDDDDE
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0325--Glycoprotein
KW-0479--Metal-binding
KW-0514--Muscle protein
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0703--Sarcoplasmic reticulum
KW-0732--Signal
Interpro

IPR001393--Calsequestrin
IPR018233--Calsequestrin_CS
IPR012336--Thioredoxin-like_fold
PROSITE

PS00863--CALSEQUESTRIN_1
PS00864--CALSEQUESTRIN_2
Pfam

PF01216--Calsequestrin
Gene Ontology

GO:0034704--C:calcium channel complex
GO:0005737--C:cytoplasm
GO:0005622--C:intracellular
GO:0030314--C:junctional membrane complex
GO:0014701--C:junctional sarcoplasmic reticulum membrane
GO:0016529--C:sarcoplasmic reticulum
GO:0033018--C:sarcoplasmic reticulum lumen
GO:0033017--C:sarcoplasmic reticulum membrane
GO:0030018--C:Z disc
GO:0005509--F:calcium ion binding
GO:0048306--F:calcium-dependent protein binding
GO:0042803--F:protein homodimerization activity
GO:0060048--P:cardiac muscle contraction
GO:0071313--P:cellular response to caffeine
GO:0005513--P:detection of calcium ion
GO:0034220--P:ion transmembrane transport
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:0043267--P:negative regulation of potassium ion transport
GO:0060315--P:negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0051258--P:protein polymerization
GO:0086029--P:Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:0010881--P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010649--P:regulation of cell communication by electrical coupling
GO:0002027--P:regulation of heart rate
GO:0060306--P:regulation of membrane repolarization
GO:0010880--P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0045214--P:sarcomere organization
GO:0051208--P:sequestering of calcium ion
GO:0006941--P:striated muscle contraction
GO:0055085--P:transmembrane transport