dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000801
Uniprot Accession O14950; ML12B_HUMAN; D3DUH6; Q13182; Q7Z5Z4;
Genbank Protein ID NP_001138416.1; NP_001138417.1; NP_001289978.1; NP_291024.1;
Genbank Nucleotide ID NM_001144944.1; NM_001144945.1; NM_001303049.1; NM_033546.3;
Protein Name Myosin regulatory light chain 12B
Protein Synonyms/Alias MLC-2A;MLC-2;Myosin regulatory light chain 2-B, smooth muscle isoform;Myosin regulatory light chain 20 kDa;MLC20;Myosin regulatory light chain MRLC2;SHUJUN-1;
Gene Name MYL12B
Gene Synonyms/Alias MRLC2;MYLC2B;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
10SKKAKTKTTKKRPQRPhosphoSitePlus22135298
11KKAKTKTTKKRPQRAdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
19KKRPQRATSNVFAMFdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated11942626; 12429016; 15946647; 16381945; 23193290; 11278951;
20KRPQRATSNVFAMFDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated11942626; 12429016; 15946647; 16381945; 23193290; 10233893;
29VFAMFDQSQIQEFKEdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22199227; 19690332;
60DLHDMLASLGKNPTDPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 20068231
97FGEKLNGTDPEDVIRPhosphoSitePlus22135298
128DYLRELLTTMGDRFTHPRD 9;PhosphoSitePlus;curated20068231; 18988627; 22135298
135TTMGDRFTDEEVDELdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated19690332; 6593002; 16381945; 23193290; 19060867; 22135298; 2
143DEEVDELYREAPIDKdbPTM 3.0;PhosphoSitePlus;curated20562096; 16381945; 23193290; 22135298; 22817900
156DKKGNFNYIEFTRILdbPTM 3.0;PhosphoSitePlus21253578; 16381945; 23193290; 22135298
Sequence
(Fasta)		MSSKKAKTKT TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID KEDLHDMLAS 60
LGKNPTDAYL DAMMNEAPGP INFTMFLTMF GEKLNGTDPE DVIRNAFACF DEEATGTIQE 120
DYLRELLTTM GDRFTDEEVD ELYREAPIDK KGNFNYIEFT RILKHGAKDK DD 173
Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0505--Motor protein
KW-0514--Muscle protein
KW-0518--Myosin
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
PROSITE

PS00018--EF_HAND_1
PS50222--EF_HAND_2
Pfam

PF13499--EF-hand_7
Gene Ontology

GO:0045177--C:apical part of cell
GO:0005903--C:brush border
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016460--C:myosin II complex
GO:0001725--C:stress fiber
GO:0030018--C:Z disc
GO:0005509--F:calcium ion binding
GO:0007411--P:axon guidance
GO:0048013--P:ephrin receptor signaling pathway
GO:0006936--P:muscle contraction
GO:0008360--P:regulation of cell shape
GO:0007264--P:small GTPase mediated signal transduction