dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000798
Uniprot Accession O14944; EREG_HUMAN; B2RC66; Q6FH69;
Genbank Protein ID NP_001423.1;
Genbank Nucleotide ID NM_001432.2;
Protein Name Proepiregulin
Protein Synonyms/Alias
Gene Name EREG
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
144TYYFCRWYRNRKSKEPhosphoSitePlus22135298
Sequence
(Fasta)		MTAGRRMEML CAGRVPALLL CLGFHLLQAV LSTTVIPSCI PGESSDNCTA LVQTEDNPRV 60
AQVSITKCSS DMNGYCLHGQ CIYLVDMSQN YCRCEVGYTG VRCEHFFLTV HQPLSKEYVA 120
LTVILIILFL ITVVGSTYYF CRWYRNRKSK EPKKEYERVT SGDPELPQV
Keyword

KW-0002--3D-structure
KW-0037--Angiogenesis
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0339--Growth factor
KW-0472--Membrane
KW-0497--Mitogen
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR015497--EGF_rcpt_ligand
PROSITE

PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
Pfam
Gene Ontology

GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005887--C:integral component of plasma membrane
GO:0005622--C:intracellular
GO:0005154--F:epidermal growth factor receptor binding
GO:0008083--F:growth factor activity
GO:0000187--P:activation of MAPK activity
GO:0000186--P:activation of MAPKK activity
GO:0009653--P:anatomical structure morphogenesis
GO:0001525--P:angiogenesis
GO:0007411--P:axon guidance
GO:0007267--P:cell-cell signaling
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0007143--P:female meiotic division
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0030216--P:keratinocyte differentiation
GO:0043616--P:keratinocyte proliferation
GO:0042700--P:luteinizing hormone signaling pathway
GO:0000165--P:MAPK cascade
GO:0009299--P:mRNA transcription
GO:0008285--P:negative regulation of cell proliferation
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0051151--P:negative regulation of smooth muscle cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0001556--P:oocyte maturation
GO:0009887--P:organ morphogenesis
GO:0001550--P:ovarian cumulus expansion
GO:0030728--P:ovulation
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0008284--P:positive regulation of cell proliferation
GO:0042108--P:positive regulation of cytokine biosynthetic process
GO:0001819--P:positive regulation of cytokine production
GO:0045740--P:positive regulation of DNA replication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0045089--P:positive regulation of innate immune response
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0045840--P:positive regulation of mitotic nuclear division
GO:0042327--P:positive regulation of phosphorylation
GO:0045860--P:positive regulation of protein kinase activity
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0048160--P:primary follicle stage
GO:0007265--P:Ras protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0042060--P:wound healing