dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000797
Uniprot Accession O14939; PLD2_HUMAN; I3L2C9; O43540; O43579; O43580; Q6PGR0; Q96BY3;
Genbank Protein ID NP_001230037.1; NP_002654.3;
Genbank Nucleotide ID NM_001243108.1; NM_002663.4;
Protein Name Phospholipase D2
Protein Synonyms/Alias
Gene Name PLD2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May have a role in signal-induced cytoskeletal regulation and/or endocytosis.
Phosphorylation Sites
 dbPAF PTMs: 27 (View all)
PositionPeptidesSourceReferences ( PMIDs )
29MESDEVDTLKEGEDPPhosphoSitePlus22135298
72VTAQVVGTERYTSGSdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15979581; 16381945; 23193290; 22135298; 22817900
77VGTERYTSGSKVGTCPhosphoSitePlus22135298
79TERYTSGSKVGTCTLPhosphoSitePlus;curated22135298; 23911959
99THGDFSWTTKKKYRHdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15979581; 16381945; 23193290; 22135298; 22817900
100HGDFSWTTKKKYRHFdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15979581; 16381945; 23193290; 22135298; 22817900
134ARFAVAYSPARDAGNdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15979581; 16381945; 23193290; 18625302; 22135298; 23186163;
146AGNREMPSLPRAGPEdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15979581; 16381945; 23193290; 22135298; 22817900; 24961811
156RAGPEGSTRHAASKQPhosphoSitePlus22135298
161GSTRHAASKQKYLENPhosphoSitePlus22135298
169KQKYLENYLNRLLTMdbPTM 3.0;PhosphoSitePlus;curated16407827; 20647543; 16381945; 23193290; 22135298; 22817900
175NYLNRLLTMSFYRNYdbPTM 3.0;PhosphoSitePlus;curated18006275; 16381945; 23193290; 22135298; 22817900
179RLLTMSFYRNYHAMTdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated16407827; 18006275; 19715678; 20647543; 16381945; 23193290;
213EGMIRKRSGGHRVPGPhosphoSitePlus22135298
243RWLVVKDSFLLYMCLdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15979581; 16381945; 23193290; 22135298; 22817900
252LLYMCLETGAISFVQdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15979581; 16381945; 23193290; 22135298; 22817900
296LILKCSSYRQARWWAdbPTM 3.0;PhosphoSitePlus;curated19715678; 20176813; 20647543; 16381945; 23193290; 22135298;
415ALGINSGYSKRALMLdbPTM 3.0;PhosphoSitePlus;curated19715678; 20176813; 21414324; 16381945; 23193290; 22135298;
416LGINSGYSKRALMLLPhosphoSitePlus22135298
488SAASQPPTPRPDSPAPhosphoSitePlus;curated22135298; 23898821
Sequence
(Fasta)		MTATPESLFP TGDELDSSQL QMESDEVDTL KEGEDPADRM HPFLAIYELQ SLKVHPLVFA 60
PGVPVTAQVV GTERYTSGSK VGTCTLYSVR LTHGDFSWTT KKKYRHFQEL HRDLLRHKVL 120
MSLLPLARFA VAYSPARDAG NREMPSLPRA GPEGSTRHAA SKQKYLENYL NRLLTMSFYR 180
NYHAMTEFLE VSQLSFIPDL GRKGLEGMIR KRSGGHRVPG LTCCGRDQVC YRWSKRWLVV 240
KDSFLLYMCL ETGAISFVQL FDPGFEVQVG KRSTEARHGV RIDTSHRSLI LKCSSYRQAR 300
WWAQEITELA QGPGRDFLQL HRHDSYAPPR PGTLARWFVN GAGYFAAVAD AILRAQEEIF 360
ITDWWLSPEV YLKRPAHSDD WRLDIMLKRK AEEGVRVSIL LFKEVELALG INSGYSKRAL 420
MLLHPNIKVM RHPDQVTLWA HHEKLLVVDQ VVAFLGGLDL AYGRWDDLHY RLTDLGDSSE 480
SAASQPPTPR PDSPATPDLS HNQFFWLGKD YSNLITKDWV QLDRPFEDFI DRETTPRMPW 540
RDVGVVVHGL PARDLARHFI QRWNFTKTTK AKYKTPTYPY LLPKSTSTAN QLPFTLPGGQ 600
CTTVQVLRSV DRWSAGTLEN SILNAYLHTI RESQHFLYIE NQFFISCSDG RTVLNKVGDE 660
IVDRILKAHK QGWCYRVYVL LPLLPGFEGD ISTGGGNSIQ AILHFTYRTL CRGEYSILHR 720
LKAAMGTAWR DYISICGLRT HGELGGHPVS ELIYIHSKVL IADDRTVIIG SANINDRSLL 780
GKRDSELAVL IEDTETEPSL MNGAEYQAGR FALSLRKHCF GVILGANTRP DLDLRDPICD 840
DFFQLWQDMA ESNANIYEQI FRCLPSNATR SLRTLREYVA VEPLATVSPP LARSELTQVQ 900
GHLVHFPLKF LEDESLLPPL GSKEGMIPLE VWT 934
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR001683--Phox
IPR025202--PLD-like_dom
IPR001736--PLipase_D/transphosphatidylase
IPR016555--PLipase_D1/D2
IPR015679--PLipase_D_fam
PROSITE

PS50035--PLD
PS50195--PX
Pfam

PF00614--PLDc
PF13091--PLDc_2
PF00787--PX
Gene Ontology

GO:0031526--C:brush border membrane
GO:0005789--C:endoplasmic reticulum membrane
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0031982--C:vesicle
GO:0070290--F:N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0035091--F:phosphatidylinositol binding
GO:0004630--F:phospholipase D activity
GO:0048870--P:cell motility
GO:0007010--P:cytoskeleton organization
GO:0006887--P:exocytosis
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0002031--P:G-protein coupled receptor internalization
GO:0046474--P:glycerophospholipid biosynthetic process
GO:0045087--P:innate immune response
GO:0048017--P:inositol lipid-mediated signaling
GO:0006643--P:membrane lipid metabolic process
GO:0006654--P:phosphatidic acid biosynthetic process
GO:0046473--P:phosphatidic acid metabolic process
GO:0006655--P:phosphatidylglycerol biosynthetic process
GO:0009395--P:phospholipid catabolic process
GO:0006644--P:phospholipid metabolic process
GO:0030334--P:regulation of cell migration
GO:0050764--P:regulation of phagocytosis
GO:0060627--P:regulation of vesicle-mediated transport
GO:0007264--P:small GTPase mediated signal transduction
GO:0044281--P:small molecule metabolic process
GO:0036465--P:synaptic vesicle recycling