dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000796
Uniprot Accession O14936; CSKP_HUMAN; A6NES1; B7ZKY0; O43215; Q17RI4; Q59HA0; Q5VT16; Q5VT17; Q5VT18; Q5VT19; Q66T42; Q9BYH6; Q9NYB2; Q9NYB3;
Genbank Protein ID NP_001119526.1; NP_001119527.1; NP_003679.2;
Genbank Nucleotide ID NM_001126054.2; NM_001126055.2; NM_003688.3;
Protein Name Peripheral plasma membrane protein CASK
Protein Synonyms/Alias
Gene Name CASK
Gene Synonyms/Alias LIN2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
Phosphorylation Sites
 dbPAF PTMs: 35 (View all)
PositionPeptidesSourceReferences ( PMIDs )
49IVDVAKFTSSPGLSTdbPTM 3.0;HPRD 9;curated18691976; 16381945; 23193290; 18988627; 22199227
50VDVAKFTSSPGLSTEPhosphoSitePlus;curated22135298; 25627689; 22199227
51DVAKFTSSPGLSTEDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25850435;
151PHCVLLASKENSAPVdbPTM 3.0;PhosphoSitePlus18423203; 16381945; 23193290; 22135298
155LLASKENSAPVKLGGdbPTM 3.0;PhosphoSitePlus18423203; 16381945; 23193290; 22135298
282WLKERDRYAYKIHLPPhosphoSitePlus22135298
313GAVLAAVSSHKFNSFPhosphoSitePlus;UniProt;curated22135298; 24275569; 25627689; 23898821; 24972180
314AVLAAVSSHKFNSFYPhosphoSitePlus;curated22135298; 25627689; 23898821
319VSSHKFNSFYGDPPEPhosphoSitePlus22135298
387LHTLLDLYDKINTKSPhosphoSitePlus22135298
394YDKINTKSSPQIRNPdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 25627689; 23898821
395DKINTKSSPQIRNPPcurated25627689
460SDEALRVTPPPTSPYPhosphoSitePlus;curated22135298; 26074081
465RVTPPPTSPYLNGDSPhosphoSitePlus22135298
562MLREMRGSITFKIVPcurated25404012
570ITFKIVPSYRTQSSSPhosphoSitePlus22135298
571TFKIVPSYRTQSSSCPhosphoSitePlus22135298
573KIVPSYRTQSSSCERPhosphoSitePlus22135298
575VPSYRTQSSSCERDScurated23898821
577SYRTQSSSCERDSPScurated25627689; 23898821
Sequence
(Fasta)		MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS SPGLSTEDLK 60
REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC FEIVKRADAG FVYSEAVASH 120
YMRQILEALR YCHDNNIIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV 180
GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR 240
QWSHISESAK DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 300
RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGL LAAERAVSQV LDSLEEIHAL 360
TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN PPSDAVQRAK EVLEEISCYP 420
ENNDAKELKR ILTQPHFMAL LQTHDVVAHE VYSDEALRVT PPPTSPYLNG DSPESANGDM 480
DMENVTRVRL VQFQKNTDEP MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN 540
GISVANQTVE QLQKMLREMR GSITFKIVPS YRTQSSSCER DSPSTSRQSP ANGHSSTNNS 600
VSDLPSTTQP KGRQIYVRAQ FEYDPAKDDL IPCKEAGIRF RVGDIIQIIS KDDHNWWQGK 660
LENSKNGTAG LIPSPELQEW RVACIAMEKT KQEQQASCTW FGKKKKQYKD KYLAKHNAVF 720
DQLDLVTYEE VVKLPAFKRK TLVLLGAHGV GRRHIKNTLI TKHPDRFAYP IPHTTRPPKK 780
DEENGKNYYF VSHDQMMQDI SNNEYLEYGS HEDAMYGTKL ETIRKIHEQG LIAILDVEPQ 840
ALKVLRTAEF APFVVFIAAP TITPGLNEDE SLQRLQKESD ILQRTYAHYF DLTIINNEID 900
ETIRHLEEAV ELVCTAPQWV PVSWVY 927
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0112--Calmodulin-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0418--Kinase
KW-0472--Membrane
KW-0991--Mental retardation
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase
Interpro

IPR008145--GK/Ca_channel_bsu
IPR008144--Guanylate_kin-like_dom
IPR020590--Guanylate_kinase_CS
IPR011009--Kinase-like_dom
IPR014775--L27_C
IPR004172--L27_dom
IPR027417--P-loop_NTPase
IPR001478--PDZ
IPR000719--Prot_kinase_dom
IPR002290--Ser/Thr_dual-sp_kinase
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS00856--GUANYLATE_KINASE_1
PS50052--GUANYLATE_KINASE_2
PS51022--L27
PS50106--PDZ
PS50011--PROTEIN_KINASE_DOM
PS50002--SH3
Pfam

PF00625--Guanylate_kin
PF02828--L27
PF00595--PDZ
PF00069--Pkinase
PF07653--SH3_2
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005604--C:basement membrane
GO:0016323--C:basolateral plasma membrane
GO:0005911--C:cell-cell junction
GO:0060170--C:ciliary membrane
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0005652--C:nuclear lamina
GO:0016363--C:nuclear matrix
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:0042734--C:presynaptic membrane
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0004385--F:guanylate kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0070509--P:calcium ion import
GO:0007155--P:cell adhesion
GO:0030198--P:extracellular matrix organization
GO:0046710--P:GDP metabolic process
GO:0046037--P:GMP metabolic process
GO:0001953--P:negative regulation of cell-matrix adhesion
GO:0090288--P:negative regulation of cellular response to growth factor stimulus
GO:0010839--P:negative regulation of keratinocyte proliferation
GO:0061045--P:negative regulation of wound healing
GO:0007269--P:neurotransmitter secretion
GO:0090280--P:positive regulation of calcium ion import
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007268--P:synaptic transmission