| Tag |
Content |
| dbPAF ID |
dbPAF-0000795 |
| Uniprot Accession |
O14933; UB2L6_HUMAN; A6NDM6; A8MY53; Q8N5D8; Q9UEZ0;
|
| Genbank Protein ID |
NP_004214.1; NP_937826.1;
|
| Genbank Nucleotide ID |
NM_004223.4; NM_198183.2;
|
| Protein Name |
Ubiquitin/ISG15-conjugating enzyme E2 L6 |
| Protein Synonyms/Alias |
E2 ubiquitin-conjugating enzyme L6;Retinoic acid-induced gene B protein;RIG-B;UbcH8;Ubiquitin carrier protein L6;Ubiquitin-protein ligase L6; |
| Gene Name |
UBE2L6 |
| Gene Synonyms/Alias |
UBCH8; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.Functional Description
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 26 | PPYLRNLSSDDANVL | PhosphoSitePlus;curated | 22135298; 23090842 |
|
Sequence
(Fasta) | MMASMRVVKE LEDLQKKPPP YLRNLSSDDA NVLVWHALLL PDQPPYHLKA FNLRISFPPE 60
YPFKPPMIKF TTKIYHPNVD ENGQICLPII SSENWKPCTK TCQVLEALNV LVNRPNIREP 120
LRMDLADLLT QNPELFRKNA EEFTLRFGVD RPS
154Fasta Sequence
>O14933|UBE2L6|Homo sapiens(Human)
MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
|
| Interpro |
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
|
| PROSITE |
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
|
| Pfam |
PF00179--UQ_con
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0042296--F:ISG15 transferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0019221--P:cytokine-mediated signaling pathway
GO:0006281--P:DNA repair
GO:0045087--P:innate immune response
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process
GO:0032480--P:negative regulation of type I interferon production
GO:0019985--P:translesion synthesis
|
