dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000791
Uniprot Accession O14924; RGS12_HUMAN; B1AQ30; B1AQ31; B1AQ32; B7Z764; E7EMN9; O14922; O14923; O43510; O75338; Q147X0; Q8WX95;
Genbank Protein ID NP_002917.1; NP_937870.1; NP_937872.1; XP_006713968.1; XP_006713969.1; XP_006713970.1; XP_011511844.1; XP_011511845.1;
Genbank Nucleotide ID NM_002926.3; NM_198227.1; NM_198229.2; XM_006713905.1; XM_006713906.2; XM_006713907.1; XM_011513542.1; XM_011513543.1;
Protein Name Regulator of G-protein signaling 12
Protein Synonyms/Alias
Gene Name RGS12
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Phosphorylation Sites
 dbPAF PTMs: 31 (View all)
PositionPeptidesSourceReferences ( PMIDs )
16KRPLPGPSPPRVRSVPhosphoSitePlus;curated22135298; 23898821
88VKLIGKCSGVLHMVIdbPTM 3.017287340; 16381945; 23193290
106VGRFESCSSDEEGGLPhosphoSitePlus;curated22135298; 25849741
107GRFESCSSDEEGGLYPhosphoSitePlus;curated22135298; 25850435; 25849741
172KLKQRSLSESAATRFcurated25850435; 23898821; 22798277; 25849741
195NPNPNMLSKEEISKVcurated25849741
284MHDCVQLSTDKAGVVdbPTM 3.017525332; 16381945; 23193290
435NFHQEEKSNRVLVVDPhosphoSitePlus22135298
483FCPDPEGSPPFEAAHPhosphoSitePlus22135298
492PFEAAHQTDRFWDLNPhosphoSitePlus22135298
649QRTSARRSFGRSKRFPhosphoSitePlus22135298
671DLESATVSDGELTGAPhosphoSitePlus22135298
676TVSDGELTGADLKDCPhosphoSitePlus22135298
697SSNASLPSVQSCRRLPhosphoSitePlus22135298
700ASLPSVQSCRRLRERPhosphoSitePlus22135298
849PDSQQVPSSPASKHScurated23090842
850DSQQVPSSPASKHSLdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298; 25850435; 23911959;
856SSPASKHSLGSDHSSPhosphoSitePlus;curated22135298; 25849741
865GSDHSSVSTPKKLSGcurated23898821
866SDHSSVSTPKKLSGKPhosphoSitePlus22135298
Sequence
(Fasta)		MFRAGEASKR PLPGPSPPRV RSVEVARGRA GYGFTLSGQA PCVLSCVMRG SPADFVGLRA 60
GDQILAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGVG RFESCSSDEE GGLYEGKGWL 120
KPKLDSKALG INRAERVVEE MQSGGIFNMI FENPSLCASN SEPLKLKQRS LSESAATRFD 180
VGHESINNPN PNMLSKEEIS KVIHDDSVFS IGLESHDDFA LDASILNVAM IVGYLGSIEL 240
PSTSSNLESD SLQAIRGCMR RLRAEQKIHS LVTMKIMHDC VQLSTDKAGV VAEYPAEKLA 300
FSAVCPDDRR FFGLVTMQTN DDGSLAQEEE GALRTSCHVF MVDPDLFNHK IHQGIARRFG 360
FECTADPDTN GCLEFPASSL PVLQFISVLY RDMGELIEGM RARAFLDGDA DAHQNNSTSS 420
NSDSGIGNFH QEEKSNRVLV VDLGGSSSRH GPGGSAWDGV GGRGAQPWGA PWTGPFCPDP 480
EGSPPFEAAH QTDRFWDLNK HLGPASPVEV PPASLRSSVP PSKRGTVGAG CGFNQRWLPV 540
HVLREWQCGH TSDQDSYTDS TDGWSSINCG TLPPPMSKIP ADRYRVEGSF AQPPLNAPKR 600
EWSRKAFGMQ SIFGPHRNVR KTKEDKKGSK FGRGTGLTQP SQRTSARRSF GRSKRFSITR 660
SLDDLESATV SDGELTGADL KDCVSNNSLS SNASLPSVQS CRRLRERRVA SWAVSFERLL 720
QDPVGVRYFS DFLRKEFSEE NILFWQACEY FNHVPAHDKK ELSYRAREIF SKFLCSKATT 780
PVNIDSQAQL ADDVLRAPHP DMFKEQQLQI FNLMKFDSYT RFLKSPLYQE CILAEVEGRA 840
LPDSQQVPSS PASKHSLGSD HSSVSTPKKL SGKSKSGRSL NEELGDEDSE KKRKGAFFSW 900
SRTRSTGRSQ KKREHGDHAD DALHANGGLC RRESQGSVSS AGSLDLSEAC RTLAPEKDKA 960
TKHCCIHLPD GTSCVVAVKA GFSIKDILSG LCERHGINGA AADLFLVGGD KPLVLHQDSS 1020
ILESRDLRLE KRTLFRLDLV PINRSVGLKA KPTKPVTEVL RPVVARYGLD LSGLLVRLSG 1080
EKEPLDLGAP ISSLDGQRVV LEEKDPSRGK ASADKQKGVP VKQNTAVNSS SRNHSATGEE 1140
RTLGKSNSIK IKGENGKNAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN 1200
RADDQRGLLR KEDLVLPEFL RLPPGSTELT LPTPAAVAKG FSKRSATGNG RESASQPGEQ 1260
WEPVQESSDS PSTSPGSASS PPGPPGTTPP GQKSPSGPFC TPQSPVSLAQ EGTAQIWKRQ 1320
SQEVEAGGIQ TVEDEHVAEL TLMGEGDISS PNSTLLPPPS TPQEVPGPSR PGSGTHGSRD 1380
LPVNRIIDVD LVTGSAPGRD GGIAGAQAGP GRSQASGGPP TSDLPGLGPV PGEPAKPKTS 1440
AHHATFV 1448
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0734--Signal transduction inhibitor
KW-0804--Transcription
KW-0832--Ubl conjugation
Interpro

IPR003109--GoLoco_motif
IPR001478--PDZ
IPR011993--PH/PTB_dom
IPR006020--PTB/PI_dom
IPR003116--Raf-like_ras-bd
IPR016137--RGS
IPR024066--RGS_subdom1
IPR029071--Ubiquitin-rel_dom
PROSITE

PS50877--GOLOCO
PS50106--PDZ
PS01179--PID
PS50898--RBD
PS50132--RGS
Pfam

PF02188--GoLoco
PF00595--PDZ
PF02196--RBD
PF00615--RGS
Gene Ontology

GO:0000794--C:condensed nuclear chromosome
GO:0016363--C:nuclear matrix
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0030695--F:GTPase regulator activity
GO:0005057--F:receptor signaling protein activity
GO:0009968--P:negative regulation of signal transduction
GO:0043547--P:positive regulation of GTPase activity
GO:0050790--P:regulation of catalytic activity
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006351--P:transcription, DNA-templated