dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000790
Uniprot Accession O14921; RGS13_HUMAN; Q6PGR2; Q8TD63; Q9BX45;
Genbank Protein ID NP_002918.1; NP_658912.1;
Genbank Nucleotide ID NM_002927.4; NM_144766.2;
Protein Name Regulator of G-protein signaling 13
Protein Synonyms/Alias
Gene Name RGS13
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
41SFENLMATKYGPVVYdbPTM 3.0;PhosphoSitePlus;curated20974683; 16381945; 23193290; 22135298; 22817900
48TKYGPVVYAAYLKMEPhosphoSitePlus22135298
51GPVVYAAYLKMEHSDPhosphoSitePlus22135298
146RFLKSEMYQKLLKTMPhosphoSitePlus22135298
Sequence
(Fasta)		MSRRNCWICK MCRDESKRPP SNLTLEEVLQ WAQSFENLMA TKYGPVVYAA YLKMEHSDEN 60
IQFWMACETY KKIASRWSRI SRAKKLYKIY IQPQSPREIN IDSSTRETII RNIQEPTETC 120
FEEAQKIVYM HMERDSYPRF LKSEMYQKLL KTMQSNNSF
Keyword

KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0734--Signal transduction inhibitor
Interpro

IPR016137--RGS
IPR024066--RGS_subdom1
PROSITE

PS50132--RGS
Pfam

PF00615--RGS
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0045744--P:negative regulation of G-protein coupled receptor protein signaling pathway
GO:0043547--P:positive regulation of GTPase activity