| Tag |
Content |
| dbPAF ID |
dbPAF-0000787 |
| Uniprot Accession |
O14910; LIN7A_HUMAN; A4FTY3; Q147W1; Q6LES3; Q7LDS4;
|
| Genbank Protein ID |
NP_004655.1;
|
| Genbank Nucleotide ID |
NM_004664.2;
|
| Protein Name |
Protein lin-7 homolog A |
| Protein Synonyms/Alias |
|
| Gene Name |
LIN7A |
| Gene Synonyms/Alias |
MALS1;VELI1; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.Functional Description
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MLKPSVTSAP TADMATLTVV QPLTLDRDVA RAIELLEKLQ ESGEVPVHKL QSLKKVLQSE 60
FCTAIREVYQ YMHETITVNG CPEFRARATA KATVAAFAAS EGHSHPRVVE LPKTDEGLGF 120
NVMGGKEQNS PIYISRIIPG GVAERHGGLK RGDQLLSVNG VSVEGEHHEK AVELLKAAKD 180
SVKLVVRYTP KVLEEMEARF EKLRTARRRQ QQQLLIQQQQ QQQQQQTQQN HMS
234Fasta Sequence
>O14910|LIN7A|Homo sapiens(Human)
MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS
|
| Keyword |
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0268--Exocytosis
KW-0472--Membrane
KW-0628--Postsynaptic cell membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0770--Synapse
KW-0771--Synaptosome
KW-0796--Tight junction
KW-0813--Transport
|
| Interpro |
IPR014775--L27_C
IPR004172--L27_dom
IPR001478--PDZ
|
| PROSITE |
PS51022--L27
PS50106--PDZ
|
| Pfam |
PF02828--L27
PF00595--PDZ
|
| Gene Ontology |
GO:0016323--C:basolateral plasma membrane
GO:0005923--C:bicellular tight junction
GO:0005911--C:cell-cell junction
GO:0070062--C:extracellular exosome
GO:0097025--C:MPP7-DLG1-LIN7 complex
GO:0043005--C:neuron projection
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0045202--C:synapse
GO:0097016--F:L27 domain binding
GO:0008105--P:asymmetric protein localization
GO:0006887--P:exocytosis
GO:0048839--P:inner ear development
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0007269--P:neurotransmitter secretion
GO:0006461--P:protein complex assembly
GO:1903361--P:protein localization to basolateral plasma membrane
GO:0015031--P:protein transport
GO:0007268--P:synaptic transmission
GO:0048489--P:synaptic vesicle transport
|
