dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000785
Uniprot Accession O14907; TX1B3_HUMAN; B2RD53; D3DTJ6; Q7LCQ4;
Genbank Protein ID NP_001191627.1; NP_055419.1;
Genbank Nucleotide ID NM_001204698.1; NM_014604.3;
Protein Name Tax1-binding protein 3
Protein Synonyms/Alias Glutaminase-interacting protein 3;Tax interaction protein 1;TIP-1;Tax-interacting protein 1;
Gene Name TAX1BP3
Gene Synonyms/Alias TIP1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
2------MSYIPGQPVcurated25627689
3-----MSYIPGQPVTcurated25627689
42GGIDQDPSQNPFSEDPhosphoSitePlus22135298
58TDKGIYVTRVSEGGPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated18669648; 16381945; 23193290; 20068231; 18988627; 21081558;
61GIYVTRVSEGGPAEIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 20068231; 18988627; 21081558;
110EVVRLLVTRQSLQKAPhosphoSitePlus22135298
124AVQQSMLS-------dbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
Sequence
(Fasta)		MSYIPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK TDKGIYVTRV 60
SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR SEEVVRLLVT RQSLQKAVQQ 120
SMLS 125
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0879--Wnt signaling pathway
Interpro

IPR001478--PDZ
IPR017268--Tax1-binding_p3
PROSITE

PS50106--PDZ
Pfam

PF00595--PDZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0008022--F:protein C-terminus binding
GO:0090630--P:activation of GTPase activity
GO:0008285--P:negative regulation of cell proliferation
GO:2000009--P:negative regulation of protein localization to cell surface
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0007266--P:Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0016055--P:Wnt signaling pathway