dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000783
Uniprot Accession O14901; KLF11_HUMAN; B4DZE7; Q9EPF4;
Genbank Protein ID NP_001171187.1; NP_001171189.1; NP_003588.1; XP_005246236.1;
Genbank Nucleotide ID NM_001177716.1; NM_001177718.1; NM_003597.4; XM_005246179.3;
Protein Name Krueppel-like factor 11
Protein Synonyms/Alias Transforming growth factor-beta-inducible early growth response protein 2;TGFB-inducible early growth response protein 2;TIEG-2;
Gene Name KLF11
Gene Synonyms/Alias FKLF;TIEG2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
32LERKRHDSERSTCSIcurated24702127
73LLRIRPLTPVSDSGDdbPTM 3.0;PhosphoSitePlus;curated12006497; 16381945; 23193290; 22135298; 22817900
82VSDSGDVTTTVHMDAPhosphoSitePlus22135298
83SDSGDVTTTVHMDAAPhosphoSitePlus22135298
107SLSTLCITPPQSPDLcurated20873877
111LCITPPQSPDLVEPSdbPTM 3.0;PhosphoSitePlus;curated12006497; 16381945; 23193290; 22135298; 20873877; 22817900
124PSTRTPVSPQVTDSKdbPTM 3.0;PhosphoSitePlus;curated12006497; 16381945; 23193290; 22135298; 25850435; 25627689;
150AVVARALSGGAERGLPhosphoSitePlus22135298
165LGLEPVPSSPCRAKGcurated25627689
166GLEPVPSSPCRAKGTdbPTM 3.0;PhosphoSitePlus;curated12006497; 16381945; 23193290; 22135298; 25627689; 22817900
258GWPGAVQTCSPKNYEcurated25627689
260PGAVQTCSPKNYENDcurated25627689
417HLKAHLRTHTGEKPFPhosphoSitePlus22135298
419KAHLRTHTGEKPFNCPhosphoSitePlus22135298
447ELSRHRRTHTGEKKFPhosphoSitePlus22135298
449SRHRRTHTGEKKFVCPhosphoSitePlus22135298
470FMRSDHLTKHARRHMcurated26074081
503ASAESPGSPLVSMPAcurated25627689
Sequence
(Fasta)		MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA LVCMSSWGQR 60
SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS LSTLCITPPQ SPDLVEPSTR 120
TPVSPQVTDS KACTATDVLQ SSAVVARALS GGAERGLLGL EPVPSSPCRA KGTSVIRHTG 180
ESPAACFPTI QTPDCRLSDS REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG 240
LLLTDKGQQA GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP 300
AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP PAPCAANVMA 360
AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG CRKTYFKSSH LKAHLRTHTG 420
EKPFNCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD RRFMRSDHLT KHARRHMTTK 480
KIPGWQAEVG KLNRIASAES PGSPLVSMPA SA 513
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0219--Diabetes mellitus
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00096--zf-C2H2
Gene Ontology

GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0006915--P:apoptotic process
GO:0008285--P:negative regulation of cell proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0043065--P:positive regulation of apoptotic process
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0006366--P:transcription from RNA polymerase II promoter