dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000782
Uniprot Accession O14896; IRF6_HUMAN; B4DLE2; D3DT90; F5GWX8; G0ZTL0;
Genbank Protein ID NP_001193625.1; NP_006138.1;
Genbank Nucleotide ID NM_001206696.1; NM_006147.3;
Protein Name Interferon regulatory factor 6
Protein Synonyms/Alias
Gene Name IRF6
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
44QIPWKHATRHSPQQEcurated23090842
47WKHATRHSPQQEEENcurated23090842; 22798277
97SREFNLMYDGTKEVPPhosphoSitePlus22135298
128GSIINPGSTGSAPWDcurated23090842
129SIINPGSTGSAPWDEcurated23090842
131INPGSTGSAPWDEKDcurated23090842
312EVSGHAIYAIRLCQCPhosphoSitePlus22135298
413FSGDFTRSFDSGSVRdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 23090842; 22817900
416DFTRSFDSGSVRLQIdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 23090842; 22817900
418TRSFDSGSVRLQISTcurated23090842
424GSVRLQISTPDIKDNPhosphoSitePlus;curated22135298; 23090842; 25849741
457QPMQPTPSMQLPPALPhosphoSitePlus22135298
Sequence
(Fasta)		MALHPRRVRL KPWLVAQVDS GLYPGLIWLH RDSKRFQIPW KHATRHSPQQ EEENTIFKAW 60
AVETGKYQEG VDDPDPAKWK AQLRCALNKS REFNLMYDGT KEVPMNPVKI YQVCDIPQPQ 120
GSIINPGSTG SAPWDEKDND VDEEDEEDEL DQSQHHVPIQ DTFPFLNING SPMAPASVGN 180
CSVGNCSPEA VWPKTEPLEM EVPQAPIQPF YSSPELWISS LPMTDLDIKF QYRGKEYGQT 240
MTVSNPQGCR LFYGDLGPMP DQEELFGPVS LEQVKFPGPE HITNEKQKLF TSKLLDVMDR 300
GLILEVSGHA IYAIRLCQCK VYWSGPCAPS LVAPNLIERQ KKVKLFCLET FLSDLIAHQK 360
GQIEKQPPFE IYLCFGEEWP DGKPLERKLI LVQVIPVVAR MIYEMFSGDF TRSFDSGSVR 420
LQISTPDIKD NIVAQLKQLY RILQTQESWQ PMQPTPSMQL PPALPPQ 468
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR019817--Interferon_reg_fac_CS
IPR001346--Interferon_reg_fact_DNA-bd_dom
IPR019471--Interferon_reg_factor-3
IPR017855--SMAD_dom-like
IPR008984--SMAD_FHA_domain
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS00601--IRF_1
PS51507--IRF_2
Pfam

PF00605--IRF
PF10401--IRF-3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0000975--F:regulatory region DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0007050--P:cell cycle arrest
GO:0048468--P:cell development
GO:0019221--P:cytokine-mediated signaling pathway
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0030216--P:keratinocyte differentiation
GO:0043616--P:keratinocyte proliferation
GO:0060644--P:mammary gland epithelial cell differentiation
GO:0008285--P:negative regulation of cell proliferation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0060337--P:type I interferon signaling pathway