dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000781
Uniprot Accession O14893; GEMI2_HUMAN; B2R9W8; Q2M3B3; Q9H4F5; Q9NS77; Q9NS78; Q9NS79;
Genbank Protein ID NP_001009182.1; NP_001009183.1; NP_003607.1;
Genbank Nucleotide ID NM_001009182.1; NM_001009183.1; NM_003616.2;
Protein Name Gem-associated protein 2
Protein Synonyms/Alias
Gene Name GEMIN2
Gene Synonyms/Alias SIP1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Phosphorylation Sites
dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
48DPSVPPRTPQEYLRRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18220336; 16381945; 23193290; 18669648; 19276368; 18988627;
52PPRTPQEYLRRVQIEPHOSIDA21081558
81KKLKRKQSVNISLSGPhosphoSitePlus;UniProt;curated22135298; 24275569; 23898821
85RKQSVNISLSGCQPAcurated23898821
131WKSQQLDSNVTMPKSPHOSIDA21081558
166VGPATNESPGIDYVQdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 16381945; 23193290; 18988627; 21081558; 22135298;
171NESPGIDYVQIGFPPdbPTM 3.0;HPRD 9;PhosphoSitePlus19413330; 16381945; 23193290; 18988627; 22135298
Sequence
(Fasta)
MRRAELAGLK TMAWVPAESA VEELMPRLLP VEPCDLTEGF DPSVPPRTPQ EYLRRVQIEA 60
AQCPDVVVAQ IDPKKLKRKQ SVNISLSGCQ PAPEGYSPTL QWQQQQVAQF STVRQNVNKH 120
RSHWKSQQLD SNVTMPKSED EEGWKKFCLG EKLCADGAVG PATNESPGID YVQIGFPPLL 180
SIVSRMNQAT VTSVLEYLSN WFGERDFTPE LGRWLYALLA CLEKPLLPEA HSLIRQLARR 240
CSEVRLLVDS KDDERVPALN LLICLVSRYF DQRDLADEPS 281
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR017364--GEMIN2

PROSITE
Pfam
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0097504--C:Gemini of coiled bodies
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0032797--C:SMN complex
GO:0034719--C:SMN-Sm protein complex
GO:0005681--C:spliceosomal complex
GO:0010467--P:gene expression
GO:0006397--P:mRNA processing
GO:0034660--P:ncRNA metabolic process
GO:0008380--P:RNA splicing
GO:0000375--P:RNA splicing, via transesterification reactions
GO:0000245--P:spliceosomal complex assembly
GO:0000387--P:spliceosomal snRNP assembly