dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000779
Uniprot Accession O14879; IFIT3_HUMAN; Q99634; Q9BSK7;
Genbank Protein ID NP_001026853.1; NP_001540.2;
Genbank Nucleotide ID NM_001031683.3; NM_001549.5;
Protein Name Interferon-induced protein with tetratricopeptide repeats 3
Protein Synonyms/Alias
Gene Name IFIT3
Gene Synonyms/Alias CIG-49;IFI60;IFIT4;ISG60;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
Phosphorylation Sites
 dbPAF PTMs: 16
PositionPeptidesSourceReferences ( PMIDs )
8MSEVTKNSLEKILPQcurated25849741
54TEFKATMYNLLAYIKPhosphoSitePlus22135298
59TMYNLLAYIKHLDGNPhosphoSitePlus22135298
135SNPYSIEYSELDCEEdbPTM 3.0;PhosphoSitePlus;curated20562096; 16381945; 23193290; 22135298; 22817900
192NHPEKQFSTDVLKQAdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
193HPEKQFSTDVLKQAIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18988627; 21081558; 22135298;
203LKQAIELSPDNQYVKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16964243; 18669648; 18691976; 16381945; 23193290; 20068231;
208ELSPDNQYVKVLLGLdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 19060867; 22135298; 22817900
237VEEALEKSPCQTDVLdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 16381945; 23193290; 20068231; 18988627; 21081558;
271FQRVLESTPNNGYLYPhosphoSitePlus;curated22135298; 25627689
313MIEALKQYAMDYSNKPhosphoSitePlus;curated22135298; 22817900
374LQKYNGKSEDTAVQHdbPTM 3.0;PhosphoSitePlus;curated20164059; 16381945; 23193290; 22135298; 23090842; 22817900
377YNGKSEDTAVQHGLEcurated23090842
477MGQGAVSSSPRELLSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;curated18669648; 16381945; 23193290; 18988627; 22817900
478GQGAVSSSPRELLSNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated18669648; 16381945; 23193290; 20068231; 18988627; 21081558;
484SSPRELLSNSEQLN-curated23090842
Sequence
(Fasta)		MSEVTKNSLE KILPQLKCHF TWNLFKEDSV SRDLEDRVCN QIEFLNTEFK ATMYNLLAYI 60
KHLDGNNEAA LECLRQAEEL IQQEHADQAE IRSLVTWGNY AWVYYHLGRL SDAQIYVDKV 120
KQTCKKFSNP YSIEYSELDC EEGWTQLKCG RNERAKVCFE KALEEKPNNP EFSSGLAIAM 180
YHLDNHPEKQ FSTDVLKQAI ELSPDNQYVK VLLGLKLQKM NKEAEGEQFV EEALEKSPCQ 240
TDVLRSAAKF YRRKGDLDKA IELFQRVLES TPNNGYLYHQ IGCCYKAKVR QMQNTGESEA 300
SGNKEMIEAL KQYAMDYSNK ALEKGLNPLN AYSDLAEFLE TECYQTPFNK EVPDAEKQQS 360
HQRYCNLQKY NGKSEDTAVQ HGLEGLSISK KSTDKEEIKD QPQNVSENLL PQNAPNYWYL 420
QGLIHKQNGD LLQAAKCYEK ELGRLLRDAP SGIGSIFLSA SELEDGSEEM GQGAVSSSPR 480
ELLSNSEQLN 491
Keyword

KW-0051--Antiviral defense
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
Interpro

IPR024122--Interferon-induced_IFIT3
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR001440--TPR_1
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF00515--TPR_1
PF13414--TPR_11
PF13181--TPR_8
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0042802--F:identical protein binding
GO:0003723--F:RNA binding
GO:0035457--P:cellular response to interferon-alpha
GO:0019221--P:cytokine-mediated signaling pathway
GO:0051607--P:defense response to virus
GO:0043066--P:negative regulation of apoptotic process
GO:0008285--P:negative regulation of cell proliferation
GO:0009615--P:response to virus
GO:0060337--P:type I interferon signaling pathway