Tag |
Content |
dbPAF ID |
dbPAF-0000777 |
Uniprot Accession |
O14867; BACH1_HUMAN; O43285; Q6ICU0; |
Genbank Protein ID |
NP_001177.1; NP_996749.1; |
Genbank Nucleotide ID |
NM_001186.3; NM_206866.2; |
Protein Name |
Transcription regulator protein BACH1 |
Protein Synonyms/Alias |
BTB and CNC homolog 1;HA2303; |
Gene Name |
BACH1 |
Gene Synonyms/Alias |
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Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.Functional Description
Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.
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Phosphorylation Sites
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dbPAF PTMs: 23 (View all) |
Sequence (Fasta) | MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS VLAACSSYFH 60 SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK ENVDEVCKCV EFLSVHNIEE 120 SCFQFLKFKF LDSTADQQEC PRKKCFSSHC QKTDLKLSLL DQRDLETDEV EEFLENKNVQ 180 TPQCKLRRYQ GNAKASPPLQ DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR 240 TGESSVKDIH ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP 300 TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP LSGTDVQEKT 360 FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG FWSDICSTDT PCQMQLSPAV 420 AKDGSEQISQ KRSECPWLGI RISESPEPGQ RTFTTLSSVN CPFISTLSTE GCSSNLEIGN 480 DDYVSEPQQE PCPYACVISL GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND 540 FQSLLKMHKL TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL 600 KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF LISEKDKSTP 660 DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ MSTATSEQAG PAEQCRQSGG 720 ISDFCQQMTD KCTTDE
737Fasta Sequence
>O14867|BACH1|Homo sapiens(Human) MSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEPLIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLENKNVQTPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVRTGESSVKDIHASVQPNERSENECLGGVPECRDLQVMLKCDESKLAMEPEETKKDPASQCPTEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGDLNFAGMQNTTVLTEKPLSGTDVQEKTFGESQDLPLKSDLGTREDSSVASSDRSSVEREVAEHLAKGFWSDICSTDTPCQMQLSPAVAKDGSEQISQKRSECPWLGIRISESPEPGQRTFTTLSSVNCPFISTLSTEGCSSNLEIGNDDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLCQKVCKEAALSQEQIQILAKYSAADCPLSFLISEKDKSTPDGELALPSIFSLSDRPPAVLPPCARGNSEPGYARGQESQQMSTATSEQAGPAEQCRQSGGISDFCQQMTDKCTTDE
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Keyword |
KW-0002--3D-structure KW-0010--Activator KW-0181--Complete proteome KW-0238--DNA-binding KW-0539--Nucleus KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation
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Interpro |
IPR000210--BTB/POZ_dom IPR004827--bZIP IPR004826--bZIP_Maf IPR011333--POZ_dom IPR008917--TF_DNA-bd
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PROSITE |
PS50097--BTB PS50217--BZIP PS00036--BZIP_BASIC
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Pfam |
PF00651--BTB PF03131--bZIP_Maf
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Gene Ontology |
GO:0031463--C:Cul3-RING ubiquitin ligase complex GO:0005737--C:cytoplasm GO:0005634--C:nucleus GO:0020037--F:heme binding GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding GO:0003700--F:transcription factor activity, sequence-specific DNA binding GO:0001205--F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0006281--P:DNA repair GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0016567--P:protein ubiquitination GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000117--P:regulation of transcription involved in G2/M transition of mitotic cell cycle GO:0006355--P:regulation of transcription, DNA-templated
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