dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000777
Uniprot Accession O14867; BACH1_HUMAN; O43285; Q6ICU0;
Genbank Protein ID NP_001177.1; NP_996749.1;
Genbank Nucleotide ID NM_001186.3; NM_206866.2;
Protein Name Transcription regulator protein BACH1
Protein Synonyms/Alias BTB and CNC homolog 1;HA2303;
Gene Name BACH1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.
Phosphorylation Sites
dbPAF PTMs: 23 (View all)
PositionPeptidesSourceReferences ( PMIDs )
158QKTDLKLSLLDQRDLPhosphoSitePlus;curated22135298; 25627689
181LENKNVQTPQCKLRRPhosphoSitePlus22135298
196YQGNAKASPPLQDSAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated15302935; 16381945; 23193290; 18452278; 18988627; 19060867;
236KFQKAFGTDRVRTGEPhosphoSitePlus22135298
321SIDPHGLYSLSLLHTdbPTM 3.0;curated19369195; 16381945; 23193290
322IDPHGLYSLSLLHTYdbPTM 3.019369195; 16381945; 23193290
328YSLSLLHTYDQYGDLdbPTM 3.019369195; 16381945; 23193290
360GTDVQEKTFGESQDLPhosphoSitePlus;curated22135298; 25627689
364QEKTFGESQDLPLKSPhosphoSitePlus;curated22135298; 25627689; 23917254
379DLGTREDSSVASSDRPhosphoSitePlus22135298
383REDSSVASSDRSSVEcurated23898821
384EDSSVASSDRSSVERcurated23898821
387SVASSDRSSVEREVAcurated25627689; 23898821
388VASSDRSSVEREVAEPhosphoSitePlus;curated22135298; 25627689; 24961811
417TPCQMQLSPAVAKDGPhosphoSitePlus;curated22135298; 25850435; 25627689; 26074081
443PWLGIRISESPEPGQcurated24961811
445LGIRISESPEPGQRTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated15302935; 16964243; 18669648; 16381945; 23193290; 20068231;
504VISLGDDSETDTEGDPhosphoSitePlus22135298
506SLGDDSETDTEGDSEPhosphoSitePlus22135298
543LSRNDFQSLLKMHKLPhosphoSitePlus;curated22135298; 23186163
Sequence
(Fasta)
MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS VLAACSSYFH 60
SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK ENVDEVCKCV EFLSVHNIEE 120
SCFQFLKFKF LDSTADQQEC PRKKCFSSHC QKTDLKLSLL DQRDLETDEV EEFLENKNVQ 180
TPQCKLRRYQ GNAKASPPLQ DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR 240
TGESSVKDIH ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP 300
TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP LSGTDVQEKT 360
FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG FWSDICSTDT PCQMQLSPAV 420
AKDGSEQISQ KRSECPWLGI RISESPEPGQ RTFTTLSSVN CPFISTLSTE GCSSNLEIGN 480
DDYVSEPQQE PCPYACVISL GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND 540
FQSLLKMHKL TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL 600
KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF LISEKDKSTP 660
DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ MSTATSEQAG PAEQCRQSGG 720
ISDFCQQMTD KCTTDE 737
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR000210--BTB/POZ_dom
IPR004827--bZIP
IPR004826--bZIP_Maf
IPR011333--POZ_dom
IPR008917--TF_DNA-bd

PROSITE

PS50097--BTB
PS50217--BZIP
PS00036--BZIP_BASIC

Pfam

PF00651--BTB
PF03131--bZIP_Maf

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0020037--F:heme binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001205--F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0006281--P:DNA repair
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000117--P:regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0006355--P:regulation of transcription, DNA-templated