| Tag |
Content |
| dbPAF ID |
dbPAF-0000775 |
| Uniprot Accession |
O14862; AIM2_HUMAN; A8K7M7; Q5T3V9; Q96FG9;
|
| Genbank Protein ID |
NP_004824.1;
|
| Genbank Nucleotide ID |
NM_004833.1;
|
| Protein Name |
Interferon-inducible protein AIM2 |
| Protein Synonyms/Alias |
Absent in melanoma 2; |
| Gene Name |
AIM2 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.Functional Description
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MESKYKEILL LTGLDNITDE ELDRFKFFLS DEFNIATGKL HTANRIQVAT LMIQNAGAVS 60
AVMKTIRIFQ KLNYMLLAKR LQEEKEKVDK QYKSVTKPKP LSQAEMSPAA SAAIRNDVAK 120
QRAAPKVSPH VKPEQKQMVA QQESIREGFQ KRCLPVMVLK AKKPFTFETQ EGKQEMFHAT 180
VATEKEFFFV KVFNTLLKDK FIPKRIIIIA RYYRHSGFLE VNSASRVLDA ESDQKVNVPL 240
NIIRKAGETP KINTLQTQPL GTIVNGLFVV QKVTEKKKNI LFDLSDNTGK MEVLGVRNED 300
TMKCKEGDKV RLTFFTLSKN GEKLQLTSGV HSTIKVIKAK KKT
344Fasta Sequence
>O14862|AIM2|Homo sapiens(Human)
MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT
|
| Keyword |
KW-0002--3D-structure
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0399--Innate immunity
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0043--Tumor suppressor
|
| Interpro |
IPR004020--DAPIN
IPR011029--DEATH-like_dom
IPR004021--HIN200/IF120x
IPR012340--NA-bd_OB-fold
|
| PROSITE |
PS50824--DAPIN
PS50834--HIN_200
|
| Pfam |
PF02760--HIN
PF02758--PYRIN
|
| Gene Ontology |
GO:0097169--C:AIM2 inflammasome complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003690--F:double-stranded DNA binding
GO:0042802--F:identical protein binding
GO:0002218--P:activation of innate immune response
GO:0006915--P:apoptotic process
GO:0035690--P:cellular response to drug
GO:0035458--P:cellular response to interferon-beta
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0050702--P:interleukin-1 beta secretion
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0035872--P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:2001056--P:positive regulation of cysteine-type endopeptidase activity
GO:0002230--P:positive regulation of defense response to virus by host
GO:0032731--P:positive regulation of interleukin-1 beta production
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0032461--P:positive regulation of protein oligomerization
GO:0070269--P:pyroptosis
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
|
