| Tag |
Content |
| dbPAF ID |
dbPAF-0000774 |
| Uniprot Accession |
O14842; FFAR1_HUMAN; Q0VAS2; Q4VBL4;
|
| Genbank Protein ID |
NP_005294.1;
|
| Genbank Nucleotide ID |
NM_005303.2;
|
| Protein Name |
Free fatty acid receptor 1 |
| Protein Synonyms/Alias |
G-protein coupled receptor 40; |
| Gene Name |
FFAR1 |
| Gene Synonyms/Alias |
GPR40; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.Functional Description
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MDLPPQLSFG LYVAAFALGF PLNVLAIRGA TAHARLRLTP SLVYALNLGC SDLLLTVSLP 60
LKAVEALASG AWPLPASLCP VFAVAHFFPL YAGGGFLAAL SAGRYLGAAF PLGYQAFRRP 120
CYSWGVCAAI WALVLCHLGL VFGLEAPGGW LDHSNTSLGI NTPVNGSPVC LEAWDPASAG 180
PARFSLSLLL FFLPLAITAF CYVGCLRALA RSGLTHRRKL RAAWVAGGAL LTLLLCVGPY 240
NASNVASFLY PNLGGSWRKL GLITGAWSVV LNPLVTGYLG RGPGLKTVCA ARTQGGKSQK 300
301Fasta Sequence
>O14842|FFAR1|Homo sapiens(Human)
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
|
| Keyword |
KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
IPR013312--GPR40-rel_orph
IPR013313--GPR40_recept_FA
|
| PROSITE |
PS50262--G_PROTEIN_RECEP_F1_2
|
| Pfam |
PF00001--7tm_1
|
| Gene Ontology |
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0045125--F:bioactive lipid receptor activity
GO:0004930--F:G-protein coupled receptor activity
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0008289--F:lipid binding
GO:0006112--P:energy reserve metabolic process
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0042593--P:glucose homeostasis
GO:0030073--P:insulin secretion
GO:0051928--P:positive regulation of calcium ion transport
GO:0043547--P:positive regulation of GTPase activity
GO:0032024--P:positive regulation of insulin secretion
GO:0050796--P:regulation of insulin secretion
GO:0070542--P:response to fatty acid
GO:0044281--P:small molecule metabolic process
|
