dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000773
Uniprot Accession O14841; OPLA_HUMAN; A5PKY8; Q75W65; Q9Y4Q0;
Genbank Protein ID NP_060040.1;
Genbank Nucleotide ID NM_017570.4;
Protein Name 5-oxoprolinase
Protein Synonyms/Alias 5-oxo-L-prolinase;5-OPase;Pyroglutamase;
Gene Name OPLAH
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
81IASIRMGTTVATNALPhosphoSitePlus22135298
82ASIRMGTTVATNALLPhosphoSitePlus22135298
149LHRGEAGTGTPVKGRcurated23898821
151RGEAGTGTPVKGRTGPhosphoSitePlus;curated22135298; 23917254; 25404012
570QAQGFPRSQISTESFPHOSIDA21081558
576RSQISTESFLHLRYQPHOSIDA21081558
763LQRTAISTNIKERLDPhosphoSitePlus22135298
1037VTLSALIYCLRCLVGPHOSIDA21081558
1065RVVIPRGSILDPSPEdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
1265DPAPPPGSPPQALAFcurated26074081
Sequence
(Fasta)		MGSPEGRFHF AIDRGGTFTD VFAQCPGGHV RVLKLLSEDP ANYADAPTEG IRRILEQEAG 60
MLLPRDQPLD SSHIASIRMG TTVATNALLE RKGERVALLV TRGFRDLLHI GTQARGDLFD 120
LAVPMPEVLY EEVLEVDERV VLHRGEAGTG TPVKGRTGDL LEVQQPVDLG ALRGKLEGLL 180
SRGIRSLAVV LMHSYTWAQH EQQVGVLARE LGFTHVSLSS EAMPMVRIVP RGHTACADAY 240
LTPAIQRYVQ GFCRGFQGQL KDVQVLFMRS DGGLAPMDTF SGSSAVLSGP AGGVVGYSAT 300
TYQQEGGQPV IGFDMGGTST DVSRYAGEFE HVFEASTAGV TLQAPQLDIN TVAAGGGSRL 360
FFRSGLFVVG PESAGAHPGP ACYRKGGPVT VTDANLVLGR LLPASFPCIF GPGENQPLSP 420
EASRKALEAV ATEVNSFLTN GPCPASPLSL EEVAMGFVRV ANEAMCRPIR ALTQARGHDP 480
SAHVLACFGG AGGQHACAIA RALGMDTVHI HRHSGLLSAL GLALADVVHE AQEPCSLLYA 540
PETFVQLDQR LSRLEEQCVD ALQAQGFPRS QISTESFLHL RYQGTDCALM VSAHQHPATA 600
RSPRAGDFGA AFVERYMREF GFVIPERPVV VDDVRVRGTG RSGLRLEDAP KAQTGPPRVD 660
KMTQCYFEGG YQETPVYLLA ELGYGHKLHG PCLIIDSNST ILVEPGCQAE VTKTGDICIS 720
VGAEVPGTVG PQLDPIQLSI FSHRFMSIAE QMGRILQRTA ISTNIKERLD FSCALFGPDG 780
GLVSNAPHIP VHLGAMQETV QFQIQHLGAD LHPGDVLLSN HPSAGGSHLP DLTVITPVFW 840
PGQTRPVFYV ASRGHHADIG GITPGSMPPH STMLQQEGAV FLSFKLVQGG VFQEEAVTEA 900
LRAPGKVPNC SGTRNLHDNL SDLRAQVAAN QKGIQLVGEL IGQYGLDVVQ AYMGHIQANA 960
ELAVRDMLRA FGTSRQARGL PLEVSSEDHM DDGSPIRLRV QISLSQGSAV FDFSGTGPEV 1020
FGNLNAPRAV TLSALIYCLR CLVGRDIPLN QGCLAPVRVV IPRGSILDPS PEAAVVGGNV 1080
LTSQRVVDVI LGAFGACAAS QGCMNNVTLG NAHMGYYETV AGGAGAGPSW HGRSGVHSHM 1140
TNTRITDPEI LESRYPVILR RFELRRGSGG RGRFRGGDGV TRELLFREEA LLSVLTERRA 1200
FRPYGLHGGE PGARGLNLLI RKNGRTVNLG GKTSVTVYPG DVFCLHTPGG GGYGDPEDPA 1260
PPPGSPPQAL AFPEHGSVYE YRRAQEAV 1289
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR008040--Hydant_A_N
IPR002821--Hydantoinase_A
IPR003692--Hydantoinase_B
PROSITE
Pfam

PF05378--Hydant_A_N
PF01968--Hydantoinase_A
PF02538--Hydantoinase_B
Gene Ontology

GO:0005829--C:cytosol
GO:0017168--F:5-oxoprolinase (ATP-hydrolyzing) activity
GO:0005524--F:ATP binding
GO:0006750--P:glutathione biosynthetic process
GO:1901687--P:glutathione derivative biosynthetic process
GO:0044281--P:small molecule metabolic process
GO:0006805--P:xenobiotic metabolic process