| Tag |
Content |
| dbPAF ID |
dbPAF-0000772 |
| Uniprot Accession |
O14836; TR13B_HUMAN; B2R8B0; B7Z6V8; Q32LX4; Q7Z6F5;
|
| Genbank Protein ID |
NP_036584.1;
|
| Genbank Nucleotide ID |
NM_012452.2;
|
| Protein Name |
Tumor necrosis factor receptor superfamily member 13B |
| Protein Synonyms/Alias |
Transmembrane activator and CAML interactor; |
| Gene Name |
TNFRSF13B |
| Gene Synonyms/Alias |
TACI; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.Functional Description
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 110 | FCENKLRSPVNLPPE | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC KTICNHQSQR 60
TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC AYFCENKLRS PVNLPPELRR 120
QRSGEVENNS DNSGRYQGLE HRGSEASPAL PGLKLSADQV ALVYSTLGLC LCAVLCCFLV 180
AVACFLKKRG DPCSCQPRSR PRQSPAKSSQ DHAMEAGSPV STSPEPVETC SFCFPECRAP 240
TQESAVTPGT PDPTCAGRWG CHTRTTVLQP CPHIPDSGLG IVCVPAQEGG PGA
294Fasta Sequence
>O14836|TNFRSF13B|Homo sapiens(Human)
MSGLGRSRRGGRSRVDQEERFPQGLWTGVAMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAYFCENKLRSPVNLPPELRRQRSGEVENNSDNSGRYQGLEHRGSEASPALPGLKLSADQVALVYSTLGLCLCAVLCCFLVAVACFLKKRGDPCSCQPRSRPRQSPAKSSQDHAMEAGSPVSTSPEPVETCSFCFPECRAPTQESAVTPGTPDPTCAGRWGCHTRTTVLQPCPHIPDSGLGIVCVPAQEGGPGA
|
| Keyword |
KW-0002--3D-structure
KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0391--Immunity
KW-0472--Membrane
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0735--Signal-anchor
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR015384--TACI_Cys-rich-dom
IPR022317--TNFR_13B
|
| PROSITE |
PS00652--TNFR_NGFR_1
|
| Pfam |
PF09305--TACI-CRD2
|
| Gene Ontology |
GO:0009897--C:external side of plasma membrane
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0004872--F:receptor activity
GO:0002250--P:adaptive immune response
GO:0001782--P:B cell homeostasis
GO:0007166--P:cell surface receptor signaling pathway
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0030889--P:negative regulation of B cell proliferation
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
|
