| Tag |
Content |
| dbPAF ID |
dbPAF-0000770 |
| Uniprot Accession |
O14830; PPE2_HUMAN; O14831;
|
| Genbank Protein ID |
NP_006230.2; XP_011530341.1;
|
| Genbank Nucleotide ID |
NM_006239.2; XM_011532039.1;
|
| Protein Name |
Serine/threonine-protein phosphatase with EF-hands 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
PPEF2 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.Functional Description
May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MGSGTSTQHH FAFQNAERAF KAAALIQRWY RRYVARLEMR RRCTWSIFQS IEYAGQQDQV 60
KLHDFFSYLM DHFIPSSHND RDFLTRIFTE DRFAQDSEMK KCSDYESIEV PDSYTGPRLS 120
FPLLPDHATA LVEAFRLKQQ LHARYVLNLL YETKKHLVQL PNINRVSTCY SEEITVCGDL 180
HGQLDDLIFI FYKNGLPSPE RSYVFNGDFV DRGKDSVEIL MILFAFMLVY PKEFHLNRGN 240
HEDHMVNLRY GFTKEVMNKY KVHGKEILRT LQDVFCWLPL ATLIDEKVLI LHGGVSDITD 300
LELLDKIERS KIVSTMRCKT RQKSEKQMEE KRRANQKSSA QGPIPWFLPE SRSLPSSPLR 360
LGSYKAQKTS RSSSIPCSGS LDGRELSRQV RSSVELELER CRQQAGLLVT GEKEEPSRSA 420
SEADSEAGEL RKPTQEEWRQ VVDILWSDPM AQEGCKANTI RGGGCYFGPD VTQQLLQKYN 480
MQFLIRSHEC KPEGYEFCHN RKVLTIFSAS NYYEVGSNRG AYVKLGPALT PHIVQYQANK 540
VTHTLTMRQR ISRVEESALR ALREKLFAHS SDLLSEFKKH DADKVGLITL SDWAAAVESV 600
LHLGLPWRML RPQLVNSSAD NMLEYKSWLK NLAKEQLSRE NIQSSLLETL YRNRSNLETI 660
FRIIDSDHSG FISLDEFRQT WKLFSSHMNI DITDDCICDL ARSIDFNKDG HIDINEFLEA 720
FRLVEKSCPE GDASECPQAT NAKDSGCSSP GAH
754Fasta Sequence
>O14830|PPEF2|Homo sapiens(Human)
MGSGTSTQHHFAFQNAERAFKAAALIQRWYRRYVARLEMRRRCTWSIFQSIEYAGQQDQVKLHDFFSYLMDHFIPSSHNDRDFLTRIFTEDRFAQDSEMKKCSDYESIEVPDSYTGPRLSFPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSEKQMEEKRRANQKSSAQGPIPWFLPESRSLPSSPLRLGSYKAQKTSRSSSIPCSGSLDGRELSRQVRSSVELELERCRQQAGLLVTGEKEEPSRSASEADSEAGELRKPTQEEWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANKVTHTLTMRQRISRVEESALRALREKLFAHSSDLLSEFKKHDADKVGLITLSDWAAAVESVLHLGLPWRMLRPQLVNSSADNMLEYKSWLKNLAKEQLSRENIQSSLLETLYRNRSNLETIFRIIDSDHSGFISLDEFRQTWKLFSSHMNIDITDDCICDLARSIDFNKDGHIDINEFLEAFRLVEKSCPEGDASECPQATNAKDSGCSSPGAH
|
| Keyword |
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0966--Cell projection
KW-0969--Cilium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0464--Manganese
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0677--Repeat
KW-0716--Sensory transduction
KW-0844--Vision
|
| Interpro |
IPR004843--Calcineurin-like_PHP_apaH
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000048--IQ_motif_EF-hand-BS
IPR029052--Metallo-depent_PP-like
IPR013235--PPP_dom
IPR012008--Ser/Thr-Pase_EF-hand_contain
IPR006186--Ser/Thr-sp_prot-phosphatase
|
| PROSITE |
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS00125--SER_THR_PHOSPHATASE
|
| Pfam |
PF13499--EF-hand_7
PF00149--Metallophos
PF08321--PPP5
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0001917--C:photoreceptor inner segment
GO:0001750--C:photoreceptor outer segment
GO:0005509--F:calcium ion binding
GO:0030544--F:Hsp70 protein binding
GO:0051879--F:Hsp90 protein binding
GO:0005506--F:iron ion binding
GO:0030145--F:manganese ion binding
GO:0031435--F:mitogen-activated protein kinase kinase kinase binding
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0050906--P:detection of stimulus involved in sensory perception
GO:0043409--P:negative regulation of MAPK cascade
GO:0010801--P:negative regulation of peptidyl-threonine phosphorylation
GO:0006470--P:protein dephosphorylation
GO:0043506--P:regulation of JUN kinase activity
GO:0043405--P:regulation of MAP kinase activity
GO:0007601--P:visual perception
|
