dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000767
Uniprot Accession O14827; RGRF2_HUMAN; B9EG89; Q9UK56;
Genbank Protein ID NP_008840.1;
Genbank Nucleotide ID NM_006909.2;
Protein Name Ras-specific guanine nucleotide-releasing factor 2
Protein Synonyms/Alias
Gene Name RASGRF2
Gene Synonyms/Alias GRF2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
37SKKTAEASRWHEKWFPhosphoSitePlus22135298
97RDALDKQYYFTVLFGdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
465QTFIRQGSLIQVPSVPhosphoSitePlus22135298
471GSLIQVPSVERGKLSPhosphoSitePlus22135298
623ARLHKDDTDICFSKTcurated23090842
718EHLVDGKSPRLCRKFdbPTM 3.0;PhosphoSitePlus;curated20363803; 16381945; 23193290; 22135298
737PLAVSRTSSPVRARKdbPTM 3.015128856; 16381945; 23193290
746PVRARKLSLTSPLNSdbPTM 3.0;PhosphoSitePlus;UniProt;curated20363803; 21406692; 16381945; 23193290; 22135298; 22199227;
748RARKLSLTSPLNSKIPhosphoSitePlus;curated22135298; 22199227; 24702127
749ARKLSLTSPLNSKIGPhosphoSitePlus;curated22135298; 22199227
753SLTSPLNSKIGALDLPhosphoSitePlus;curated22135298; 22199227
855SPCRSPSTPRHLRYRdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
1000MKAECFESLSAMELAPhosphoSitePlus22135298
1002AECFESLSAMELAEQPhosphoSitePlus22135298
1090ICRCLHNYNGVLEITdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
1098NGVLEITSALNRSAIPhosphoSitePlus22135298
1106ALNRSAIYRLKKTWAdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
1111AIYRLKKTWAKVSKQPhosphoSitePlus22135298
Sequence
(Fasta)		MQKSVRYNEG HALYLAFLAR KEGTKRGFLS KKTAEASRWH EKWFALYQNV LFYFEGEQSC 60
RPAGMYLLEG CSCERTPAPP RAGAGQGGVR DALDKQYYFT VLFGHEGQKP LELRCEEEQD 120
GKEWMEAIHQ ASYADILIER EVLMQKYIHL VQIVETEKIA ANQLRHQLED QDTEIERLKS 180
EIIALNKTKE RMRPYQSNQE DEDPDIKKIK KVQSFMRGWL CRRKWKTIVQ DYICSPHAES 240
MRKRNQIVFT MVEAESEYVH QLYILVNGFL RPLRMAASSK KPPISHDDVS SIFLNSETIM 300
FLHEIFHQGL KARIANWPTL ILADLFDILL PMLNIYQEFV RNHQYSLQVL ANCKQNRDFD 360
KLLKQYEANP ACEGRMLETF LTYPMFQIPR YIITLHELLA HTPHEHVERK SLEFAKSKLE 420
ELSRVMHDEV SDTENIRKNL AIERMIVEGC DILLDTSQTF IRQGSLIQVP SVERGKLSKV 480
RLGSLSLKKE GERQCFLFTK HFLICTRSSG GKLHLLKTGG VLSLIDCTLI EEPDASDDDS 540
KGSGQVFGHL DFKIVVEPPD AAAFTVVLLA PSRQEKAAWM SDISQCVDNI RCNGLMTIVF 600
EENSKVTVPH MIKSDARLHK DDTDICFSKT LNSCKVPQIR YASVERLLER LTDLRFLSID 660
FLNTFLHTYR IFTTAAVVLG KLSDIYKRPF TSIPVRSLEL FFATSQNNRG EHLVDGKSPR 720
LCRKFSSPPP LAVSRTSSPV RARKLSLTSP LNSKIGALDL TTSSSPTTTT QSPAASPPPH 780
TGQIPLDLSR GLSSPEQSPG TVEENVDNPR VDLCNKLKRS IQKAVLESAP ADRAGVESSP 840
AADTTELSPC RSPSTPRHLR YRQPGGQTAD NAHCSVSPAS AFAIATAAAG HGSPPGFNNT 900
ERTCDKEFII RRTATNRVLN VLRHWVSKHA QDFELNNELK MNVLNLLEEV LRDPDLLPQE 960
RKAAANILRA LSQDDQDDIH LKLEDIIQMT DCMKAECFES LSAMELAEQI TLLDHVIFRS 1020
IPYEEFLGQG WMKLDKNERT PYIMKTSQHF NDMSNLVASQ IMNYADVSSR ANAIEKWVAV 1080
ADICRCLHNY NGVLEITSAL NRSAIYRLKK TWAKVSKQTK ALMDKLQKTV SSEGRFKNLR 1140
ETLKNCNPPA VPYLGMYLTD LAFIEEGTPN FTEEGLVNFS KMRMISHIIR EIRQFQQTSY 1200
RIDHQPKVAQ YLLDKDLIID EDTLYELSLK IEPRLPA 1238
Keyword

KW-0106--Calcium
KW-0112--Calmodulin-binding
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0344--Guanine-nucleotide releasing factor
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR000219--DH-domain
IPR000048--IQ_motif_EF-hand-BS
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR000651--Ras-like_Gua-exchang_fac_N
IPR019804--Ras_G-nucl-exch_fac_CS
IPR023578--Ras_GEF_dom
IPR001895--RASGEF_cat_dom
IPR030744--RasGRF2
PROSITE

PS50010--DH_2
PS50096--IQ
PS50003--PH_DOMAIN
PS00720--RASGEF
PS50009--RASGEF_CAT
PS50212--RASGEF_NTER
Pfam

PF00169--PH
PF00617--RasGEF
PF00618--RasGEF_N
PF00621--RhoGEF
Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0005886--C:plasma membrane
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0000186--P:activation of MAPKK activity
GO:0097190--P:apoptotic signaling pathway
GO:0007411--P:axon guidance
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0060291--P:long-term synaptic potentiation
GO:0000165--P:MAPK cascade
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0007265--P:Ras protein signal transduction
GO:2000310--P:regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0007268--P:synaptic transmission
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway