dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000766
Uniprot Accession O14818; PSA7_HUMAN; B2R515; Q5JXJ2; Q9BR53; Q9H4K5; Q9UEU8;
Genbank Protein ID NP_002783.1;
Genbank Nucleotide ID NM_002792.3;
Protein Name Proteasome subunit alpha type-7
Protein Synonyms/Alias Proteasome subunit RC6-1;Proteasome subunit XAPC7;
Gene Name PSMA7
Gene Synonyms/Alias HSPC;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
2------MSYDRAITVcurated23090842
8MSYDRAITVFSPDGHPhosphoSitePlus;curated22135298; 21857030
11DRAITVFSPDGHLFQdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
30QEAVKKGSTAVGVRGdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 22798277
106EDPVTVEYITRYIASdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298
108PVTVEYITRYIASLKdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
150RLYQTDPSGTYHAWKPhosphoSitePlus22135298
152YQTDPSGTYHAWKANPhosphoSitePlus22135298
153QTDPSGTYHAWKANAdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated16678104; 16381945; 23193290; 20090780; 19060867; 22135298;
167AIGRGAKSVREFLEKPhosphoSitePlus22135298
201ALLEVVQSGGKNIELdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25850435;
Sequence
(Fasta)		MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR 60
KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ 120
SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA 180
IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE 240
KKKQKKAS 249
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0325--Glycoprotein
KW-0945--Host-virus interaction
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0888--Threonine protease
Interpro

IPR029055--Ntn_hydrolases_N
IPR000426--Proteasome_asu_N
IPR023332--Proteasome_suA-type
IPR001353--Proteasome_sua/b
PROSITE

PS00388--PROTEASOME_ALPHA_1
PS51475--PROTEASOME_ALPHA_2
Pfam

PF00227--Proteasome
PF10584--Proteasome_A_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0005839--C:proteasome core complex
GO:0019773--C:proteasome core complex, alpha-subunit complex
GO:0004175--F:endopeptidase activity
GO:0042802--F:identical protein binding
GO:0004298--F:threonine-type endopeptidase activity
GO:0000186--P:activation of MAPKK activity
GO:0031145--P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590--P:antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474--P:antigen processing and presentation of peptide antigen via MHC class I
GO:0006915--P:apoptotic process
GO:0007411--P:axon guidance
GO:0034641--P:cellular nitrogen compound metabolic process
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0010467--P:gene expression
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0000278--P:mitotic cell cycle
GO:0043066--P:negative regulation of apoptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0038061--P:NIK/NF-kappaB signaling
GO:0006595--P:polyamine metabolic process
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0012501--P:programmed cell death
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0042981--P:regulation of apoptotic process
GO:0006521--P:regulation of cellular amino acid metabolic process
GO:0043488--P:regulation of mRNA stability
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0007264--P:small GTPase mediated signal transduction
GO:0044281--P:small molecule metabolic process
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0016032--P:viral process