dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000765
Uniprot Accession O14815; CAN9_HUMAN; B1APS1; B1AQI0; Q9NS74;
Genbank Protein ID NP_006606.1; NP_057536.1;
Genbank Nucleotide ID NM_006615.2; NM_016452.1;
Protein Name Calpain-9
Protein Synonyms/Alias Digestive tract-specific calpain;New calpain 4;nCL-4;Protein CG36;
Gene Name CAPN9
Gene Synonyms/Alias NCL4;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Calcium-regulated non-lysosomal thiol-protease.
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
170ADHNEFWSALLEKAYcurated26074081
177SALLEKAYAKLNGSYcurated26074081
228EKALKRGSLLGCFIDPhosphoSitePlus22135298
562DIKFKKLSLISCKNIPhosphoSitePlus22135298
Sequence
(Fasta)		MPYLYRAPGP QAHPVPKDAR ITHSSGQSFE QMRQECLQRG TLFEDADFPA SNSSLFYSER 60
PQIPFVWKRP GEIVKNPEFI LGGATRTDIC QGELGDCWLL AAIASLTLNQ KALARVIPQD 120
QSFGPGYAGI FHFQFWQHSE WLDVVIDDRL PTFRDRLVFL HSADHNEFWS ALLEKAYAKL 180
NGSYEALKGG SAIEAMEDFT GGVAETFQTK EAPENFYEIL EKALKRGSLL GCFIDTRSAA 240
ESEARTPFGL IKGHAYSVTG IDQVSFRGQR IELIRIRNPW GQVEWNGSWS DSSPEWRSVG 300
PAEQKRLCHT ALDDGEFWMA FKDFKAHFDK VEICNLTPDA LEEDAIHKWE VTVHQGSWVR 360
GSTAGGCRNF LDTFWTNPQI KLSLTEKDEG QEECSFLVAL MQKDRRKLKR FGANVLTIGY 420
AIYECPDKDE HLNKDFFRYH ASRARSKTFI NLREVSDRFK LPPGEYILIP STFEPHQEAD 480
FCLRIFSEKK AITRDMDGNV DIDLPEPPKP TPPDQETEEE QRFRALFEQV AGEDMEVTAE 540
ELEYVLNAVL QKKKDIKFKK LSLISCKNII SLMDTSGNGK LEFDEFKVFW DKLKQWINLF 600
LRFDADKSGT MSTYELRTAL KAAGFQLSSH LLQLIVLRYA DEELQLDFDD FLNCLVRLEN 660
ASRVFQALST KNKEFIHLNI NEFIHLTMNI 691
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
Interpro

IPR022684--Calpain_cysteine_protease
IPR022682--Calpain_domain_III
IPR022683--Calpain_III
IPR029542--CAPN9
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000169--Pept_cys_AS
IPR001300--Peptidase_C2_calpain_cat
PROSITE

PS50203--CALPAIN_CAT
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS00139--THIOL_PROTEASE_CYS
Pfam

PF01067--Calpain_III
PF00648--Peptidase_C2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005509--F:calcium ion binding
GO:0004198--F:calcium-dependent cysteine-type endopeptidase activity
GO:0007586--P:digestion
GO:0006508--P:proteolysis