| Tag |
Content |
| dbPAF ID |
dbPAF-0000764 |
| Uniprot Accession |
O14813; PHX2A_HUMAN; A8K3N0; Q8IVZ2;
|
| Genbank Protein ID |
NP_005160.2;
|
| Genbank Nucleotide ID |
NM_005169.3;
|
| Protein Name |
Paired mesoderm homeobox protein 2A |
| Protein Synonyms/Alias |
ARIX1 homeodomain protein;Aristaless homeobox protein homolog;Paired-like homeobox 2A; |
| Gene Name |
PHOX2A |
| Gene Synonyms/Alias |
ARIX;PMX2A; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.Functional Description
May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP ALGSSNCALG 60
ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA QLKELERVFA ETHYPDIYTR 120
EELALKIDLT EARVQVWFQN RRAKFRKQER AASAKGAAGA AGAKKGEARC SSEDDDSKES 180
TCSPTPDSTA SLPPPPAPGL ASPRLSPSPL PVALGSGPGP GPGPQPLKGA LWAGVAGGGG 240
GGPGAGAAEL LKAWQPAESG PGPFSGVLSS FHRKPGPALK TNLF
285Fasta Sequence
>O14813|PHOX2A|Homo sapiens(Human)
MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGAAGAKKGEARCSSEDDDSKESTCSPTPDSTASLPPPPAPGLASPRLSPSPLPVALGSGPGPGPGPQPLKGALWAGVAGGGGGGPGAGAAELLKAWQPAESGPGPFSGVLSSFHRKPGPALKTNLF
|
| Keyword |
KW-0010--Activator
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR009057--Homeodomain-like
|
| PROSITE |
PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
|
| Pfam |
PF00046--Homeobox
|
| Gene Ontology |
GO:0000790--C:nuclear chromatin
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0071542--P:dopaminergic neuron differentiation
GO:0021703--P:locus ceruleus development
GO:0030901--P:midbrain development
GO:0003357--P:noradrenergic neuron differentiation
GO:0021623--P:oculomotor nerve formation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043576--P:regulation of respiratory gaseous exchange
GO:0021523--P:somatic motor neuron differentiation
GO:0048485--P:sympathetic nervous system development
GO:0006351--P:transcription, DNA-templated
GO:0021642--P:trochlear nerve formation
|
