| Tag |
Content |
| dbPAF ID |
dbPAF-0000763 |
| Uniprot Accession |
O14810; CPLX1_HUMAN; A6NI80; B2R4R5; D3DVN3; F1T0G1;
|
| Genbank Protein ID |
NP_006642.1;
|
| Genbank Nucleotide ID |
NM_006651.3;
|
| Protein Name |
Complexin-1 |
| Protein Synonyms/Alias |
Complexin I;CPX I;Synaphin-2; |
| Gene Name |
CPLX1 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).Functional Description
Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE 60
AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV 120
IKYLPGPLQD MLKK
135Fasta Sequence
>O14810|CPLX1|Homo sapiens(Human)
MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK
|
| Keyword |
KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0268--Exocytosis
KW-0532--Neurotransmitter transport
KW-1185--Reference proteome
KW-0813--Transport
|
| Interpro |
IPR008849--Synaphin
|
| PROSITE |
|
| Pfam |
PF05835--Synaphin
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0043025--C:neuronal cell body
GO:0070032--C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070554--C:synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
GO:0043195--C:terminal bouton
GO:0005326--F:neurotransmitter transporter activity
GO:0006887--P:exocytosis
GO:0014047--P:glutamate secretion
GO:0030073--P:insulin secretion
GO:0007269--P:neurotransmitter secretion
GO:0017157--P:regulation of exocytosis
GO:0007268--P:synaptic transmission
GO:0016079--P:synaptic vesicle exocytosis
|
