| Tag |
Content |
| dbPAF ID |
dbPAF-0000760 |
| Uniprot Accession |
O14798; TR10C_HUMAN; O14755; Q08AS6; Q6FH98; Q6UXM5;
|
| Genbank Protein ID |
NP_003832.2;
|
| Genbank Nucleotide ID |
NM_003841.3;
|
| Protein Name |
Tumor necrosis factor receptor superfamily member 10C |
| Protein Synonyms/Alias |
Antagonist decoy receptor for TRAIL/Apo-2L;Decoy TRAIL receptor without death domain;Decoy receptor 1;DcR1;Lymphocyte inhibitor of TRAIL;TNF-related apoptosis-inducing ligand receptor 3;TRAIL receptor 3;TRAIL-R3;TRAIL receptor without an intracellular domain; |
| Gene Name |
TNFRSF10C |
| Gene Synonyms/Alias |
DCR1;LIT;TRAILR3;TRID;UNQ321/PRO366; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.Functional Description
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MARIPKTLKF VVVIVAVLLP VLAYSATTAR QEEVPQQTVA PQQQRHSFKG EECPAGSHRS 60
EHTGACNPCT EGVDYTNASN NEPSCFPCTV CKSDQKHKSS CTMTRDTVCQ CKEGTFRNEN 120
SPEMCRKCSR CPSGEVQVSN CTSWDDIQCV EEFGANATVE TPAAEETMNT SPGTPAPAAE 180
ETMNTSPGTP APAAEETMTT SPGTPAPAAE ETMTTSPGTP APAAEETMIT SPGTPASSHY 240
LSCTIVGIIV LIVLLIVFV
Fasta Sequence
>O14798|TNFRSF10C|Homo sapiens(Human)
MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMITSPGTPASSHYLSCTIVGIIVLIVLLIVFV
|
| Keyword |
KW-0053--Apoptosis
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0336--GPI-anchor
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
|
| Interpro |
IPR001368--TNFR/NGFR_Cys_rich_reg
IPR020465--TNFR_10
|
| PROSITE |
PS00652--TNFR_NGFR_1
PS50050--TNFR_NGFR_2
|
| Pfam |
PF00020--TNFR_c6
|
| Gene Ontology |
GO:0031225--C:anchored component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0004888--F:transmembrane signaling receptor activity
GO:0005031--F:tumor necrosis factor-activated receptor activity
GO:0008625--P:extrinsic apoptotic signaling pathway via death domain receptors
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0007275--P:multicellular organismal development
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0032496--P:response to lipopolysaccharide
GO:0007165--P:signal transduction
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
|
