dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000759
Uniprot Accession O14796; SH21B_HUMAN; B2RBN6; Q5T0L1; Q8NI18; Q969K9;
Genbank Protein ID NP_444512.2;
Genbank Nucleotide ID NM_053282.4;
Protein Name SH2 domain-containing protein 1B
Protein Synonyms/Alias EWS/FLI1-activated transcript 2;EAT-2;
Gene Name SH2D1B
Gene Synonyms/Alias EAT2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244, expressed on the surface of professional antigen-presenting cells.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
127FVNSNSDYVDVLP--PhosphoSitePlus22135298
Sequence
(Fasta)		MDLPYYHGRL TKQDCETLLL KEGVDGNFLL RDSESIPGVL CLCVSFKNIV YTYRIFREKH 60
GYYRIQTAEG SPKQVFPSLK ELISKFEKPN QGMVVHLLKP IKRTSPSLRW RGLKLELETF 120
VNSNSDYVDV LP 133
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0727--SH2 domain
Interpro

IPR000980--SH2
PROSITE

PS50001--SH2
Pfam

PF00017--SH2
Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0030674--F:protein binding, bridging
GO:0002366--P:leukocyte activation involved in immune response
GO:0045089--P:positive regulation of innate immune response
GO:0002717--P:positive regulation of natural killer cell mediated immunity
GO:0050776--P:regulation of immune response