dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000758
Uniprot Accession O14795; UN13B_HUMAN; Q2NKJ5; Q5VYM8;
Genbank Protein ID NP_006368.3; XP_011515986.1;
Genbank Nucleotide ID NM_006377.3; XM_011517684.1;
Protein Name Protein unc-13 homolog B
Protein Synonyms/Alias Munc13-2;munc13;
Gene Name UNC13B
Gene Synonyms/Alias UNC13;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 37 (View all)
PositionPeptidesSourceReferences ( PMIDs )
16KRAKFQGSPDKFNTYPhosphoSitePlus;curated22135298; 20873877; 23186163
84TVWIALKTIRQSDEEPhosphoSitePlus22135298
88ALKTIRQSDEEGPGEPhosphoSitePlus22135298
157ALGADNEYSSQEESQPhosphoSitePlus22135298
176PTAAAQCSFEDPDSAPhosphoSitePlus;UniProt;curated22135298; 24275569; 25850435; 25627689; 23663014
222QFPVPVRSPQQLLLQPhosphoSitePlus;curated22135298; 25627689; 20873877
232QLLLQGSSRDSCNDScurated23917254
243CNDSMQSYDLDYPERPhosphoSitePlus22135298
247MQSYDLDYPERRAISPhosphoSitePlus22135298
254YPERRAISPTSSSRYPhosphoSitePlus;curated22135298; 25850435; 25627689; 23663014; 25262027
295RETDSIHSCHSSHSLPhosphoSitePlus;UniProt22135298; 24275569
301HSCHSSHSLSRDGQAPhosphoSitePlus22135298
303CHSSHSLSRDGQAGFPhosphoSitePlus22135298
359HFLGPQESFPEENAScurated23090842
366SFPEENASSPFTQARcurated23898821; 23663014
367FPEENASSPFTQARAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated18669648; 16381945; 23193290; 20068231; 18988627; 21081558;
461EELKSHVYKKTLQALdbPTM 3.0;PhosphoSitePlus18083107; 16381945; 23193290; 22135298
586AHVQQMKTVKQSVLDPhosphoSitePlus22135298
605WSAKITITVVCAQGLdbPTM 3.0;HPRD 9;PhosphoSitePlus17924679; 16381945; 23193290; 15144186; 18988627; 22135298
620QAKDKTGSSDPYVTVPhosphoSitePlus22135298
Sequence
(Fasta)		MSLLCVRVKR AKFQGSPDKF NTYVTLKVQN VKSTTVAVRG DQPSWEQDFM FEISRLDLGL 60
SVEVWNKGLI WDTMVGTVWI ALKTIRQSDE EGPGEWSTLE AETLMKDDEI CGTRNPTPHK 120
ILLDTRFELP FDIPEEEARY WTYKWEQINA LGADNEYSSQ EESQRKPLPT AAAQCSFEDP 180
DSAVDDRDSD YRSETSNSFP PPYHTASQPN ASVHQFPVPV RSPQQLLLQG SSRDSCNDSM 240
QSYDLDYPER RAISPTSSSR YGSSCNVSQG SSQLSELDQY HEQDDDHRET DSIHSCHSSH 300
SLSRDGQAGF GEQEKPLEVT GQAEKEAACE PKEMKEDATT HPPPDLVLQK DHFLGPQESF 360
PEENASSPFT QARAHWIRAV TKVRLQLQEI PDDGDPSLPQ WLPEGPAGGL YGIDSMPDLR 420
RKKPLPLVSD LSLVQSRKAG ITSAMATRTS LKDEELKSHV YKKTLQALIY PISCTTPHNF 480
EVWTATTPTY CYECEGLLWG IARQGMRCSE CGVKCHEKCQ DLLNADCLQR AAEKSCKHGA 540
EDRTQNIIMA MKDRMKIRER NKPEIFEVIR DVFTVNKAAH VQQMKTVKQS VLDGTSKWSA 600
KITITVVCAQ GLQAKDKTGS SDPYVTVQVS KTKKRTKTIF GNLNPVWEEK FHFECHNSSD 660
RIKVRVWDED DDIKSRVKQR LKRESDDFLG QTIIEVRTLS GEMDVWYNLE KRTDKSAVSG 720
AIRLQISVEI KGEEKVAPYH VQYTCLHENL FHYLTDIQGS GGVRIPEARG DDAWKVYFDE 780
TAQEIVDEFA MRYGIESIYQ AMTHFACLSS KYMCPGVPAV MSTLLANINA YYAHTTASTN 840
VSASDRFAAS NFGKERFVKL LDQLHNSLRI DLSTYRNNFP AGSPERLQDL KSTVDLLTSI 900
TFFRMKVQEL QSPPRASQVV KDCVKACLNS TYEYIFNNCH DLYSRQYQLK QELPPEEQGP 960
SIRNLDFWPK LITLIVSIIE EDKNSYTPVL NQFPQELNVG KVSAEVMWHL FAQDMKYALE 1020
EHEKDHLCKS ADYMNLHFKV KWLHNEYVRD LPVLQGQVPE YPAWFEQFVL QWLDENEDVS 1080
LEFLRGALER DKKDGFQQTS EHALFSCSVV DVFTQLNQSF EIIRKLECPD PSILAHYMRR 1140
FAKTIGKVLM QYADILSKDF PAYCTKEKLP CILMNNVQQL RVQLEKMFEA MGGKELDLEA 1200
ADSLKELQVK LNTVLDELSM VFGNSFQVRI DECVRQMADI LGQVRGTGNA SPDARASAAQ 1260
DADSVLRPLM DFLDGNLTLF ATVCEKTVLK RVLKELWRVV MNTMERMIVL PPLTDQTGTQ 1320
LIFTAAKELS HLSKLKDHMV REETRNLTPK QCAVLDLALD TIKQYFHAGG NGLKKTFLEK 1380
SPDLQSLRYA LSLYTQTTDT LIKTFVRSQT TQGSGVDDPV GEVSIQVDLF THPGTGEHKV 1440
TVKVVAANDL KWQTAGMFRP FVEVTMVGPH QSDKKRKFTT KSKSNNWAPK YNETFHFLLG 1500
NEEGPESYEL QICVKDYCFA REDRVLGLAV MPLRDVTAKG SCACWCPLGR KIHMDETGLT 1560
ILRILSQRSN DEVAREFVKL KSESRSTEEG S 1592
Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0268--Exocytosis
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000008--C2_dom
IPR010439--Ca-dep_secretion_activator
IPR014770--Munc13_1
IPR014772--Munc13_dom-2
IPR019558--Munc13_subgr_dom-2
IPR002219--PE/DAG-bd
IPR027080--Unc-13
PROSITE

PS50004--C2
PS51258--MHD1
PS51259--MHD2
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00130--C1_1
PF00168--C2
PF06292--DUF1041
PF10540--Membr_traf_MHD
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031594--C:neuromuscular junction
GO:0005886--C:plasma membrane
GO:0048786--C:presynaptic active zone
GO:0043195--C:terminal bouton
GO:0019992--F:diacylglycerol binding
GO:0046872--F:metal ion binding
GO:0004872--F:receptor activity
GO:0004871--F:signal transducer activity
GO:0006915--P:apoptotic process
GO:0007588--P:excretion
GO:0014047--P:glutamate secretion
GO:0060384--P:innervation
GO:0035556--P:intracellular signal transduction
GO:0007528--P:neuromuscular junction development
GO:0007269--P:neurotransmitter secretion
GO:0097151--P:positive regulation of inhibitory postsynaptic potential
GO:0010808--P:positive regulation of synaptic vesicle priming
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0007165--P:signal transduction
GO:0007268--P:synaptic transmission
GO:0035249--P:synaptic transmission, glutamatergic
GO:0016081--P:synaptic vesicle docking
GO:0016082--P:synaptic vesicle priming