| Tag |
Content |
| dbPAF ID |
dbPAF-0000757 |
| Uniprot Accession |
O14793; GDF8_HUMAN; A1C2J7; A1C2K0; Q6B0H2;
|
| Genbank Protein ID |
NP_005250.1;
|
| Genbank Nucleotide ID |
NM_005259.2;
|
| Protein Name |
Growth/differentiation factor 8 |
| Protein Synonyms/Alias |
|
| Gene Name |
MSTN |
| Gene Synonyms/Alias |
GDF8; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Acts specifically as a negative regulator of skeletal muscle growth.Functional Description
Acts specifically as a negative regulator of skeletal muscle growth. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MQKLQLCVYI YLFMLIVAGP VDLNENSEQK ENVEKEGLCN ACTWRQNTKS SRIEAIKIQI 60
LSKLRLETAP NISKDVIRQL LPKAPPLREL IDQYDVQRDD SSDGSLEDDD YHATTETIIT 120
MPTESDFLMQ VDGKPKCCFF KFSSKIQYNK VVKAQLWIYL RPVETPTTVF VQILRLIKPM 180
KDGTRYTGIR SLKLDMNPGT GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT 240
FPGPGEDGLN PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA 300
PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM LYFNGKEQII 360
YGKIPAMVVD RCGCS
376Fasta Sequence
>O14793|MSTN|Homo sapiens(Human)
MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
|
| Keyword |
KW-0165--Cleavage on pair of basic residues
KW-0181--Complete proteome
KW-0202--Cytokine
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0339--Growth factor
KW-0358--Heparin-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR029034--Cystine-knot_cytokine
IPR015616--GDF_8
IPR001839--TGF-b_C
IPR001111--TGF-b_N
IPR015615--TGF-beta-rel
IPR017948--TGFb_CS
|
| PROSITE |
PS00250--TGF_BETA_1
PS51362--TGF_BETA_2
|
| Pfam |
PF00019--TGF_beta
PF00688--TGFb_propeptide
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005615--C:extracellular space
GO:0005125--F:cytokine activity
GO:0008083--F:growth factor activity
GO:0008201--F:heparin binding
GO:0042802--F:identical protein binding
GO:0005102--F:receptor binding
GO:0005160--F:transforming growth factor beta receptor binding
GO:0048468--P:cell development
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0098779--P:mitophagy in response to mitochondrial depolarization
GO:0046716--P:muscle cell cellular homeostasis
GO:0007517--P:muscle organ development
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0033673--P:negative regulation of kinase activity
GO:0014741--P:negative regulation of muscle hypertrophy
GO:0045662--P:negative regulation of myoblast differentiation
GO:2000818--P:negative regulation of myoblast proliferation
GO:0051898--P:negative regulation of protein kinase B signaling
GO:1902725--P:negative regulation of satellite cell differentiation
GO:1902723--P:negative regulation of skeletal muscle satellite cell proliferation
GO:0048632--P:negative regulation of skeletal muscle tissue growth
GO:0022602--P:ovulation cycle process
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010862--P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0042981--P:regulation of apoptotic process
GO:0043408--P:regulation of MAPK cascade
GO:0051602--P:response to electrical stimulus
GO:0043627--P:response to estrogen
GO:0045471--P:response to ethanol
GO:0009629--P:response to gravity
GO:0009408--P:response to heat
GO:0014850--P:response to muscle activity
GO:0033574--P:response to testosterone
GO:0014732--P:skeletal muscle atrophy
GO:0043403--P:skeletal muscle tissue regeneration
GO:0060395--P:SMAD protein signal transduction
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0098792--P:xenophagy
|
