dbPAF Protein Information
| Tag | Content | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000756 | ||||||||||||||||
| Uniprot Accession | O14792; HS3S1_HUMAN; B3KUA6; Q6PEY8; | ||||||||||||||||
| Genbank Protein ID | NP_005105.1; XP_011512215.1; | ||||||||||||||||
| Genbank Nucleotide ID | NM_005114.2; XM_011513913.1; | ||||||||||||||||
| Protein Name | Heparan sulfate glucosamine 3-O-sulfotransferase 1 | ||||||||||||||||
| Protein Synonyms/Alias | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1;3-OST-1;Heparan sulfate 3-O-sulfotransferase 1;h3-OST-1; | ||||||||||||||||
| Gene Name | HS3ST1 | ||||||||||||||||
| Gene Synonyms/Alias | 3OST;3OST1; | ||||||||||||||||
| Organism | Homo sapiens(Human) | ||||||||||||||||
| NCBI Taxa ID | 9606 | ||||||||||||||||
| Functional Description (View all) |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. | ||||||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 3
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| Sequence (Fasta) | MAALLLGAVL LVAQPQLVPS RPAELGQQEL LRKAGTLQDD VRDGVAPNGS AQQLPQTIII 60 GVRKGGTRAL LEMLSLHPDV AAAENEVHFF DWEEHYSHGL GWYLSQMPFS WPHQLTVEKT 120 PAYFTSPKVP ERVYSMNPSI RLLLILRDPS ERVLSDYTQV FYNHMQKHKP YPSIEEFLVR 180 DGRLNVDYKA LNRSLYHVHM QNWLRFFPLR HIHIVDGDRL IRDPFPEIQK VERFLKLSPQ 240 INASNFYFNK TKGFYCLRDS GRDRCLHESK GRAHPQVDPK LLNKLHEYFH EPNKKFFELV 300 GRTFDWH 308 |
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| Keyword | KW-0002--3D-structure |
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| Interpro | |||||||||||||||||
| PROSITE | |||||||||||||||||
| Pfam | PF00685--Sulfotransfer_1 |
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| Gene Ontology | GO:0005796--C:Golgi lumen |