| Tag |
Content |
| dbPAF ID |
dbPAF-0000754 |
| Uniprot Accession |
O14788; TNF11_HUMAN; O14723; Q96Q17; Q9P2Q3;
|
| Genbank Protein ID |
NP_003692.1; NP_143026.1; XP_011533582.1;
|
| Genbank Nucleotide ID |
NM_003701.3; NM_033012.3; XM_011535280.1;
|
| Protein Name |
Tumor necrosis factor ligand superfamily member 11 |
| Protein Synonyms/Alias |
Osteoclast differentiation factor;ODF;Osteoprotegerin ligand;OPGL;Receptor activator of nuclear factor kappa-B ligand;RANKL;TNF-related activation-induced cytokine;TRANCE; |
| Gene Name |
TNFSF11 |
| Gene Synonyms/Alias |
OPGL;RANKL;TRANCE; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.Functional Description
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 137 | ELQHIVGSQHIRAEK | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MRRASRDYTK YLRGSEEMGG GPGAPHEGPL HAPPPPAPHQ PPAASRSMFV ALLGLGLGQV 60
VCSVALFFYF RAQMDPNRIS EDGTHCIYRI LRLHENADFQ DTTLESQDTK LIPDSCRRIK 120
QAFQGAVQKE LQHIVGSQHI RAEKAMVDGS WLDLAKRSKL EAQPFAHLTI NATDIPSGSH 180
KVSLSSWYHD RGWAKISNMT FSNGKLIVNQ DGFYYLYANI CFRHHETSGD LATEYLQLMV 240
YVTKTSIKIP SSHTLMKGGS TKYWSGNSEF HFYSINVGGF FKLRSGEEIS IEVSNPSLLD 300
PDQDATYFGA FKVRDID
318Fasta Sequence
>O14788|TNFSF11|Homo sapiens(Human)
MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0202--Cytokine
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0987--Osteopetrosis
KW-0675--Receptor
KW-1185--Reference proteome
KW-0964--Secreted
KW-0735--Signal-anchor
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR006052--TNF_dom
IPR017355--TNF_ligand_10/11
IPR008983--Tumour_necrosis_fac-like_dom
|
| PROSITE |
PS50049--TNF_2
|
| Pfam |
PF00229--TNF
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0005125--F:cytokine activity
GO:0005164--F:tumor necrosis factor receptor binding
GO:0032813--F:tumor necrosis factor receptor superfamily binding
GO:0007257--P:activation of JUN kinase activity
GO:0045453--P:bone resorption
GO:0055074--P:calcium ion homeostasis
GO:0019221--P:cytokine-mediated signaling pathway
GO:0070371--P:ERK1 and ERK2 cascade
GO:0006955--P:immune response
GO:0060749--P:mammary gland alveolus development
GO:0033598--P:mammary gland epithelial cell proliferation
GO:0002548--P:monocyte chemotaxis
GO:0009887--P:organ morphogenesis
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0002158--P:osteoclast proliferation
GO:0038001--P:paracrine signaling
GO:0045780--P:positive regulation of bone resorption
GO:0051466--P:positive regulation of corticotropin-releasing hormone secretion
GO:0071848--P:positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
GO:0071812--P:positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0034112--P:positive regulation of homotypic cell-cell adhesion
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902533--P:positive regulation of intracellular signal transduction
GO:0043406--P:positive regulation of MAP kinase activity
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:2001206--P:positive regulation of osteoclast development
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0050870--P:positive regulation of T cell activation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0051260--P:protein homooligomerization
GO:0071847--P:TNFSF11-mediated signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
|
