dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000753
Uniprot Accession O14787; TNPO2_HUMAN; O14655; Q6IN77;
Genbank Protein ID NP_001129667.1; NP_001129668.1; NP_038461.2;
Genbank Nucleotide ID NM_001136195.1; NM_001136196.1; NM_013433.4;
Protein Name Transportin-2
Protein Synonyms/Alias Karyopherin beta-2b;
Gene Name TNPO2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
Phosphorylation Sites
dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
25KDSQSPNTATQRIVQPhosphoSitePlus22135298
57FVLTRLKSEDEPTRSdbPTM 3.0;PhosphoSitePlus21406692; 16381945; 23193290; 22135298
64SEDEPTRSLSGLILKPhosphoSitePlus;curated22135298; 22817900
66DEPTRSLSGLILKNNPhosphoSitePlus22135298
258HMHSIIQYMLQRTQDPhosphoSitePlus22135298
342PRFHKSRTVTLPHEAcurated20873877
344FHKSRTVTLPHEAERcurated20873877
355EAERPDGSEDAEDDDdbPTM 3.0;HPRD 9;curated18452278; 16381945; 23193290; 18988627; 23898821; 20873877;
Sequence
(Fasta)
MDWQPDEQGL QQVLQLLKDS QSPNTATQRI VQDKLKQLNQ FPDFNNYLIF VLTRLKSEDE 60
PTRSLSGLIL KNNVKAHYQS FPPPVADFIK QECLNNIGDA SSLIRATIGI LITTIASKGE 120
LQMWPELLPQ LCNLLNSEDY NTCEGAFGAL QKICEDSSEL LDSDALNRPL NIMIPKFLQF 180
FKHCSPKIRS HAIACVNQFI MDRAQALMDN IDTFIEHLFA LAVDDDPEVR KNVCRALVML 240
LEVRIDRLIP HMHSIIQYML QRTQDHDENV ALEACEFWLT LAEQPICKEV LASHLVQLIP 300
ILVNGMKYSE IDIILLKGDV EEDEAVPDSE QDIKPRFHKS RTVTLPHEAE RPDGSEDAED 360
DDDDDALSDW NLRKCSAAAL DVLANVFREE LLPHLLPLLK GLLFHPEWVV KESGILVLGA 420
IAEGCMQGMV PYLPELIPHL IQCLSDKKAL VRSIACWTLS RYAHWVVSQP PDMHLKPLMT 480
ELLKRILDGN KRVQEAACSA FATLEEEACT ELVPYLSYIL DTLVFAFGKY QHKNLLILYD 540
AIGTLADSVG HHLNQPEYIQ KLMPPLIQKW NELKDEDKDL FPLLECLSSV ATALQSGFLP 600
YCEPVYQRCV TLVQKTLAQA MMYTQHPEQY EAPDKDFMIV ALDLLSGLAE GLGGHVEQLV 660
ARSNIMTLLF QCMQDSMPEV RQSSFALLGD LTKACFIHVK PCIAEFMPIL GTNLNPEFIS 720
VCNNATWAIG EICMQMGAEM QPYVQMVLNN LVEIINRPNT PKTLLENTGR LTSPSAIPAI 780
TIGRLGYVCP QEVAPMLQQF IRPWCTSLRN IRDNEEKDSA FRGICMMIGV NPGGVVQDFI 840
FFCDAVASWV SPKDDLRDMF YKILHGFKDQ VGEDNWQQFS EQFPPLLKER LAAFYGV 898
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000357--HEAT
IPR001494--Importin-beta_N

PROSITE
Pfam

PF02985--HEAT
PF03810--IBN_N

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031965--C:nuclear membrane
GO:0034399--C:nuclear periphery
GO:0005634--C:nucleus
GO:0008139--F:nuclear localization sequence binding
GO:0008565--F:protein transporter activity
GO:0051148--P:negative regulation of muscle cell differentiation
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0000059--P:protein import into nucleus, docking
GO:0000060--P:protein import into nucleus, translocation
GO:0006610--P:ribosomal protein import into nucleus