dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000752
Uniprot Accession O14786; NRP1_HUMAN; B0LPG9; O60461; Q5T7F1; Q5T7F2; Q5T7F3; Q86T59; Q96I90; Q96IH5;
Genbank Protein ID NP_001019799.1; NP_001019800.1; NP_003864.4;
Genbank Nucleotide ID NM_001024628.2; NM_001024629.2; NM_003873.5;
Protein Name Neuropilin-1
Protein Synonyms/Alias Vascular endothelial cell growth factor 165 receptor;
Gene Name NRP1
Gene Synonyms/Alias NRP;VEGF165R;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
Phosphorylation Sites
 dbPAF PTMs: 24 (View all)
PositionPeptidesSourceReferences ( PMIDs )
30RNDKCGDTIKIESPGPhosphoSitePlus22135298
47TSPGYPHSYHPSEKCPhosphoSitePlus22135298
51YPHSYHPSEKCEWLIPhosphoSitePlus22135298
267ANYSVLQSSVSEDFKPhosphoSitePlus22135298
297QITASSQYSTNWSAEdbPTM 3.0;PhosphoSitePlus21653826; 16381945; 23193290; 22135298
310AERSRLNYPENGWTPPhosphoSitePlus22135298
316NYPENGWTPGEDSYRPhosphoSitePlus22135298
321GWTPGEDSYREWIQVPhosphoSitePlus22135298
322WTPGEDSYREWIQVDPhosphoSitePlus22135298
353SKETKKKYYVKTYKIPhosphoSitePlus22135298
354KETKKKYYVKTYKIDPhosphoSitePlus22135298
358KKYYVKTYKIDVSSNPhosphoSitePlus22135298
432KITDYPCSGMLGMVSPhosphoSitePlus22135298
448LISDSQITSSNQGDRPhosphoSitePlus22135298
524IGYSNNGSDWKMIMDPhosphoSitePlus22135298
827PEIKIDETGSTPGYEPhosphoSitePlus22135298
829IKIDETGSTPGYEGEPhosphoSitePlus22135298
830KIDETGSTPGYEGEGPhosphoSitePlus22135298
894GMSERNLSALENYNFdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18578522; 16381945; 23193290; 18988627; 22135298; 22199227;
899NLSALENYNFELVDGdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 18180459; 18578522; 20562096; 16381945; 23193290;
Sequence
(Fasta)		MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP SEKCEWLIQA 60
PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR GKFCGKIAPP PVVSSGPFLF 120
IKFVSDYETH GAGFSIRYEI FKRGPECSQN YTTPSGVIKS PGFPEKYPNS LECTYIVFVP 180
KMSEIILEFE SFDLEPDSNP PGGMFCRYDR LEIWDGFPDV GPHIGRYCGQ KTPGRIRSSS 240
GILSMVFYTD SAIAKEGFSA NYSVLQSSVS EDFKCMEALG MESGEIHSDQ ITASSQYSTN 300
WSAERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK KKYYVKTYKI 360
DVSSNGEDWI TIKEGNKPVL FQGNTNPTDV VVAVFPKPLI TRFVRIKPAT WETGISMRFE 420
VYGCKITDYP CSGMLGMVSG LISDSQITSS NQGDRNWMPE NIRLVTSRSG WALPPAPHSY 480
INEWLQIDLG EEKIVRGIII QGGKHRENKV FMRKFKIGYS NNGSDWKMIM DDSKRKAKSF 540
EGNNNYDTPE LRTFPALSTR FIRIYPERAT HGGLGLRMEL LGCEVEAPTA GPTTPNGNLV 600
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTVIDSTIQ SEFPTYGFNC EFGWGSHKTF 660
CHWEHDNHVQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQNSAH 720
CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ LVWMAIGHQG DHWKEGRVLL HKSLKLYQVI 780
FEGEIGKGNL GGIAVDDISI NNHISQEDCA KPADLDKKNP EIKIDETGST PGYEGEGEGD 840
KNISRKPGNV LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 900
FELVDGVKLK KDKLNTQSTY SEA 924
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0037--Angiogenesis
KW-0106--Calcium
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0357--Heparan sulfate
KW-0358--Heparin-binding
KW-0472--Membrane
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0654--Proteoglycan
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR013320--ConA-like_dom
IPR000859--CUB_dom
IPR000421--FA58C
IPR008979--Galactose-bd-like
IPR000998--MAM_dom
IPR014648--Neuropilin
IPR022579--Neuropilin1_C
IPR027146--NRP1
PROSITE

PS01180--CUB
PS01285--FA58C_1
PS01286--FA58C_2
PS50022--FA58C_3
PS00740--MAM_1
PS50060--MAM_2
Pfam

PF00431--CUB
PF11980--DUF3481
PF00754--F5_F8_type_C
PF00629--MAM
Gene Ontology

GO:0030424--C:axon
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005615--C:extracellular space
GO:0005925--C:focal adhesion
GO:0016021--C:integral component of membrane
GO:0005883--C:neurofilament
GO:0005886--C:plasma membrane
GO:0043235--C:receptor complex
GO:0002116--C:semaphorin receptor complex
GO:0097443--C:sorting endosome
GO:0015026--F:coreceptor activity
GO:0019955--F:cytokine binding
GO:0019838--F:growth factor binding
GO:0008201--F:heparin binding
GO:0046872--F:metal ion binding
GO:0017154--F:semaphorin receptor activity
GO:0038085--F:vascular endothelial growth factor binding
GO:0005021--F:vascular endothelial growth factor-activated receptor activity
GO:0001525--P:angiogenesis
GO:0060978--P:angiogenesis involved in coronary vascular morphogenesis
GO:0048844--P:artery morphogenesis
GO:0048846--P:axon extension involved in axon guidance
GO:0007411--P:axon guidance
GO:0007413--P:axonal fasciculation
GO:0060385--P:axonogenesis involved in innervation
GO:0021785--P:branchiomotor neuron axon guidance
GO:0002042--P:cell migration involved in sprouting angiogenesis
GO:0007267--P:cell-cell signaling
GO:0035729--P:cellular response to hepatocyte growth factor stimulus
GO:0035924--P:cellular response to vascular endothelial growth factor stimulus
GO:0071679--P:commissural neuron axon guidance
GO:0060982--P:coronary artery morphogenesis
GO:0016358--P:dendrite development
GO:0060666--P:dichotomous subdivision of terminal units involved in salivary gland branching
GO:0035767--P:endothelial cell chemotaxis
GO:0097102--P:endothelial tip cell fate specification
GO:0021612--P:facial nerve structural organization
GO:1903375--P:facioacoustic ganglion development
GO:0061552--P:ganglion morphogenesis
GO:0021828--P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0048012--P:hepatocyte growth factor receptor signaling pathway
GO:0048843--P:negative regulation of axon extension involved in axon guidance
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0021675--P:nerve development
GO:1901166--P:neural crest cell migration involved in autonomic nervous system development
GO:0001764--P:neuron migration
GO:0009887--P:organ morphogenesis
GO:0043049--P:otic placode formation
GO:0001569--P:patterning of blood vessels
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0050918--P:positive chemotaxis
GO:0048842--P:positive regulation of axon extension involved in axon guidance
GO:0060301--P:positive regulation of cytokine activity
GO:0010595--P:positive regulation of endothelial cell migration
GO:0001938--P:positive regulation of endothelial cell proliferation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:1902336--P:positive regulation of retinal ganglion cell axon guidance
GO:0014911--P:positive regulation of smooth muscle cell migration
GO:1902946--P:protein localization to early endosome
GO:0090259--P:regulation of retinal ganglion cell axon guidance
GO:0060627--P:regulation of vesicle-mediated transport
GO:0061441--P:renal artery morphogenesis
GO:0061299--P:retina vasculature morphogenesis in camera-type eye
GO:0031290--P:retinal ganglion cell axon guidance
GO:0071526--P:semaphorin-plexin signaling pathway
GO:1902287--P:semaphorin-plexin signaling pathway involved in axon guidance
GO:1902285--P:semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:0097374--P:sensory neuron axon guidance
GO:0007165--P:signal transduction
GO:0002040--P:sprouting angiogenesis
GO:0061549--P:sympathetic ganglion development
GO:0097490--P:sympathetic neuron projection extension
GO:0097491--P:sympathetic neuron projection guidance
GO:1901998--P:toxin transport
GO:0061551--P:trigeminal ganglion development
GO:0021637--P:trigeminal nerve structural organization
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0038190--P:VEGF-activated neuropilin signaling pathway
GO:1902378--P:VEGF-activated neuropilin signaling pathway involved in axon guidance
GO:0036486--P:ventral trunk neural crest cell migration
GO:0021649--P:vestibulocochlear nerve structural organization