dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000749
Uniprot Accession O14776; TCRG1_HUMAN; Q2NKN2; Q59EA1;
Genbank Protein ID NP_001035095.1; NP_006697.2;
Genbank Nucleotide ID NM_001040006.1; NM_006706.3;
Protein Name Transcription elongation regulator 1
Protein Synonyms/Alias TATA box-binding protein-associated factor 2S;Transcription factor CA150;
Gene Name TCERG1
Gene Synonyms/Alias CA150;TAF2S;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
11RGGDGGESERFNPGEPhosphoSitePlus;curated22135298; 23917254
422PQVAIAASPATLAGAPhosphoSitePlus22135298
438AVSEWTEYKTADGKTPhosphoSitePlus22135298
481KEPIKEPSEEPLPMEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated17924679; 16381945; 23193290; 18452278; 18988627; 22135298;
489EEPLPMETEEEDPKEdbPTM 3.0;HPRD 9;PhosphoSitePlus17924679; 16381945; 23193290; 18452278; 18988627; 22135298
591LKKLRHPTPTMLSIQPhosphoSitePlus;curated22135298; 23898821
593KLRHPTPTMLSIQKWPhosphoSitePlus;curated22135298; 23186163
638DDNKDIDSEKEAAMEPhosphoSitePlus;curated22135298; 23917254; 20873877; 23663014; 26074081
832PRYKAVDSSSMREDLcurated22199227
833RYKAVDSSSMREDLFPhosphoSitePlus;curated22135298; 25627689; 23917254
834YKAVDSSSMREDLFKPhosphoSitePlus;curated22135298; 25627689; 23917254
853KIAKNLDSEKEKELEcurated25003641; 20873877
868RQARIEASLREREREPhosphoSitePlus22135298
917MVRSSDVSWSDTRRTPhosphoSitePlus22135298
921SDVSWSDTRRTLRKDPhosphoSitePlus22135298
924SWSDTRRTLRKDHRWPhosphoSitePlus22135298
933RKDHRWESGSLLEREdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
1088RGPPPPPTASEPTRRPhosphoSitePlus22135298
1090PPPPPTASEPTRRSTPhosphoSitePlus22135298
1093PPTASEPTRRSTK--PhosphoSitePlus22135298
Sequence
(Fasta)		MAERGGDGGE SERFNPGELR MAQQQALRFR GPAPPPNAVM RGPPPLMRPP PPFGMMRGPP 60
PPPRPPFGRP PFDPNMPPMP PPGGIPPPMG PPHLQRPPFM PPPMSSMPPP PGMMFPPGMP 120
PVTAPGTPAL PPTEEIWVEN KTPDGKVYYY NARTRESAWT KPDGVKVIQQ SELTPMLAAQ 180
AQVQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ 240
AQVQAQVQAQ VQAQAVGAST PTTSSPAPAV STSTSSSTPS STTSTTTTAT SVAQTVSTPT 300
TQDQTPSSAV SVATPTVSVS TPAPTATPVQ TVPQPHPQTL PPAVPHSVPQ PTTAIPAFPP 360
VMVPPFRVPL PGMPIPLPGV AMMQIVSCPY VKTVATTKTG VLPGMAPPIV PMIHPQVAIA 420
ASPATLAGAT AVSEWTEYKT ADGKTYYYNN RTLESTWEKP QELKEKEKLE EKIKEPIKEP 480
SEEPLPMETE EEDPKEEPIK EIKEEPKEEE MTEEEKAAQK AKPVATAPIP GTPWCVVWTG 540
DERVFFYNPT TRLSMWDRPD DLIGRADVDK IIQEPPHKKG MEELKKLRHP TPTMLSIQKW 600
QFSMSAIKEE QELMEEINED EPVKAKKRKR DDNKDIDSEK EAAMEAEIKA ARERAIVPLE 660
ARMKQFKDML LERGVSAFST WEKELHKIVF DPRYLLLNPK ERKQVFDQYV KTRAEEERRE 720
KKNKIMQAKE DFKKMMEEAK FNPRATFSEF AAKHAKDSRF KAIEKMKDRE ALFNEFVAAA 780
RKKEKEDSKT RGEKIKSDFF ELLSNHHLDS QSRWSKVKDK VESDPRYKAV DSSSMREDLF 840
KQYIEKIAKN LDSEKEKELE RQARIEASLR EREREVQKAR SEQTKEIDRE REQHKREEAI 900
QNFKALLSDM VRSSDVSWSD TRRTLRKDHR WESGSLLERE EKEKLFNEHI EALTKKKREH 960
FRQLLDETSA ITLTSTWKEV KKIIKEDPRC IKFSSSDRKK QREFEEYIRD KYITAKADFR 1020
TLLKETKFIT YRSKKLIQES DQHLKDVEKI LQNDKRYLVL DCVPEERRKL IVAYVDDLDR 1080
RGPPPPPTAS EPTRRSTK 1099
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR002713--FF_domain
IPR001202--WW_dom
PROSITE

PS51676--FF
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF01846--FF
PF00397--WW
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0044822--F:poly(A) RNA binding
GO:0001103--F:RNA polymerase II repressing transcription factor binding
GO:0001106--F:RNA polymerase II transcription corepressor activity
GO:0003713--F:transcription coactivator activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter