| Tag |
Content |
| dbPAF ID |
dbPAF-0000748 |
| Uniprot Accession |
O14775; GBB5_HUMAN; B2RBR5; Q9HAU9; Q9UFT3;
|
| Genbank Protein ID |
NP_006569.1; NP_057278.2;
|
| Genbank Nucleotide ID |
NM_006578.3; NM_016194.3;
|
| Protein Name |
Guanine nucleotide-binding protein subunit beta-5 |
| Protein Synonyms/Alias |
Gbeta5;Transducin beta chain 5; |
| Gene Name |
GNB5 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.Functional Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 158 | MACAYAPSGCAIACG | PhosphoSitePlus;curated | 22135298; 24667141 |
|
Sequence
(Fasta) | MCDQTFLVNV FGSCDKCFKQ RALRPVFKKS QQLSYCSTCA EIMATEGLHE NETLASLKSE 60
AESLKGKLEE ERAKLHDVEL HQVAERVEAL GQFVMKTRRT LKGHGNKVLC MDWCKDKRRI 120
VSSSQDGKVI VWDSFTTNKE HAVTMPCTWV MACAYAPSGC AIACGGLDNK CSVYPLTFDK 180
NENMAAKKKS VAMHTNYLSA CSFTNSDMQI LTASGDGTCA LWDVESGQLL QSFHGHGADV 240
LCLDLAPSET GNTFVSGGCD KKAMVWDMRS GQCVQAFETH ESDINSVRYY PSGDAFASGS 300
DDATCRLYDL RADREVAIYS KESIIFGASS VDFSLSGRLL FAGYNDYTIN VWDVLKGSRV 360
SILFGHENRV STLRVSPDGT AFCSGSWDHT LRVWA
396Fasta Sequence
>O14775|GNB5|Homo sapiens(Human)
MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat
|
| Interpro |
IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
|
| PROSITE |
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
|
| Pfam |
PF00400--WD40
|
| Gene Ontology |
GO:0043209--C:myelin sheath
GO:0005634--C:nucleus
GO:0001917--C:photoreceptor inner segment
GO:0001750--C:photoreceptor outer segment
GO:0005886--C:plasma membrane
GO:0051087--F:chaperone binding
GO:0031682--F:G-protein gamma-subunit binding
GO:0003924--F:GTPase activity
GO:0004871--F:signal transducer activity
GO:1901386--P:negative regulation of voltage-gated calcium channel activity
GO:0007603--P:phototransduction, visible light
GO:0022400--P:regulation of rhodopsin mediated signaling pathway
GO:0016056--P:rhodopsin mediated signaling pathway
GO:0007165--P:signal transduction
|
