| Tag |
Content |
| dbPAF ID |
dbPAF-0000747 |
| Uniprot Accession |
O14773; TPP1_HUMAN; Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37;
|
| Genbank Protein ID |
NP_000382.3;
|
| Genbank Nucleotide ID |
NM_000391.3;
|
| Protein Name |
Tripeptidyl-peptidase 1 |
| Protein Synonyms/Alias |
|
| Gene Name |
TPP1 |
| Gene Synonyms/Alias |
CLN2;GIG1;UNQ267/PRO304; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).Functional Description
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MGLQACLLGL FALILSGKCS YSPEPDQRRT LPPGWVSLGR ADPEEELSLT FALRQQNVER 60
LSELVQAVSD PSSPQYGKYL TLENVADLVR PSPLTLHTVQ KWLLAAGAQK CHSVITQDFL 120
TCWLSIRQAE LLLPGAEFHH YVGGPTETHV VRSPHPYQLP QALAPHVDFV GGLHRFPPTS 180
SLRQRPEPQV TGTVGLHLGV TPSVIRKRYN LTSQDVGSGT SNNSQACAQF LEQYFHDSDL 240
AQFMRLFGGN FAHQASVARV VGQQGRGRAG IEASLDVQYL MSAGANISTW VYSSPGRHEG 300
QEPFLQWLML LSNESALPHV HTVSYGDDED SLSSAYIQRV NTELMKAAAR GLTLLFASGD 360
SGAGCWSVSG RHQFRPTFPA SSPYVTTVGG TSFQEPFLIT NEIVDYISGG GFSNVFPRPS 420
YQEEAVTKFL SSSPHLPPSS YFNASGRAYP DVAALSDGYW VVSNRVPIPW VSGTSASTPV 480
FGGILSLINE HRILSGRPPL GFLNPRLYQQ HGAGLFDVTR GCHESCLDEE VEGQGFCSGP 540
GWDPVTGWGT PNFPALLKTL LNP
564Fasta Sequence
>O14773|TPP1|Homo sapiens(Human)
MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0068--Autocatalytic cleavage
KW-0106--Calcium
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0887--Epilepsy
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0458--Lysosome
KW-0479--Metal-binding
KW-0523--Neurodegeneration
KW-0525--Neuronal ceroid lipofuscinosis
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0720--Serine protease
KW-0732--Signal
KW-0950--Spinocerebellar ataxia
KW-0865--Zymogen
|
| Interpro |
IPR015366--Peptidase_S53_propep
IPR000209--Peptidase_S8/S53_dom
IPR009020--Prot_inh_propept
IPR030400--Sedolisin_dom
|
| PROSITE |
PS51695--SEDOLISIN
|
| Pfam |
PF00082--Peptidase_S8
PF09286--Pro-kuma_activ
|
| Gene Ontology |
GO:0070062--C:extracellular exosome
GO:0043202--C:lysosomal lumen
GO:0005764--C:lysosome
GO:0042470--C:melanosome
GO:0005739--C:mitochondrion
GO:0004175--F:endopeptidase activity
GO:0046872--F:metal ion binding
GO:0008233--F:peptidase activity
GO:0042277--F:peptide binding
GO:0004252--F:serine-type endopeptidase activity
GO:0008236--F:serine-type peptidase activity
GO:0008240--F:tripeptidyl-peptidase activity
GO:0045453--P:bone resorption
GO:0044267--P:cellular protein metabolic process
GO:0007417--P:central nervous system development
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0030855--P:epithelial cell differentiation
GO:0036498--P:IRE1-mediated unfolded protein response
GO:0006629--P:lipid metabolic process
GO:0007040--P:lysosome organization
GO:0007399--P:nervous system development
GO:0050885--P:neuromuscular process controlling balance
GO:0043171--P:peptide catabolic process
GO:0030163--P:protein catabolic process
GO:0006508--P:proteolysis
|
