| Tag |
Content |
| dbPAF ID |
dbPAF-0000742 |
| Uniprot Accession |
O14763; TR10B_HUMAN; O14720; O15508; O15517; O15531; Q6UXM8; Q7Z360; Q9BVE0;
|
| Genbank Protein ID |
NP_003833.4; NP_671716.2;
|
| Genbank Nucleotide ID |
NM_003842.4; NM_147187.2;
|
| Protein Name |
Tumor necrosis factor receptor superfamily member 10B |
| Protein Synonyms/Alias |
Death receptor 5;TNF-related apoptosis-inducing ligand receptor 2;TRAIL receptor 2;TRAIL-R2; |
| Gene Name |
TNFRSF10B |
| Gene Synonyms/Alias |
DR5;KILLER;TRAILR2;TRICK2;ZTNFR9;UNQ160/PRO186; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.Functional Description
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MEQRGQNAPA ASGARKRHGP GPREARGARP GPRVPKTLVL VVAAVLLLVS AESALITQQD 60
LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD 120
SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH 180
KESGTKHSGE VPAVEETVTS SPGTPASPCS LSGIIIGVTV AAVVLIVAVF VCKSLLWKKV 240
LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV 300
NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK 360
LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH TLLDALETLG ERLAKQKIED 420
HLLSSGKFMY LEGNADSAMS
441Fasta Sequence
>O14763|TNFRSF10B|Homo sapiens(Human)
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0472--Membrane
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR011029--DEATH-like_dom
IPR000488--Death_domain
IPR001368--TNFR/NGFR_Cys_rich_reg
IPR020465--TNFR_10
|
| PROSITE |
PS50017--DEATH_DOMAIN
PS00652--TNFR_NGFR_1
PS50050--TNFR_NGFR_2
|
| Pfam |
PF00531--Death
PF00020--TNFR_c6
|
| Gene Ontology |
GO:0009986--C:cell surface
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0004872--F:receptor activity
GO:0045569--F:TRAIL binding
GO:0005031--F:tumor necrosis factor-activated receptor activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0097296--P:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0006915--P:apoptotic process
GO:0007166--P:cell surface receptor signaling pathway
GO:0071260--P:cellular response to mechanical stimulus
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0008625--P:extrinsic apoptotic signaling pathway via death domain receptors
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0007275--P:multicellular organismal development
GO:0070266--P:necroptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0012501--P:programmed cell death
GO:0097300--P:programmed necrotic cell death
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:1902041--P:regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0010939--P:regulation of necrotic cell death
GO:0034976--P:response to endoplasmic reticulum stress
GO:0032496--P:response to lipopolysaccharide
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
|
