dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000740
Uniprot Accession O14756; H17B6_HUMAN; O43275;
Genbank Protein ID NP_003716.2; XP_005269264.1; XP_005269265.1; XP_005269266.1; XP_006719735.1; XP_011537227.1; XP_011537228.1; XP_011537229.1;
Genbank Nucleotide ID NM_003725.3; XM_005269207.1; XM_005269208.1; XM_005269209.1; XM_006719672.1; XM_011538925.1; XM_011538926.1; XM_011538927.1;
Protein Name 17-beta-hydroxysteroid dehydrogenase type 6
Protein Synonyms/Alias
Gene Name HSD17B6
Gene Synonyms/Alias RODH;SDR9C6;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
202QHFGVKISIVEPGYFPhosphoSitePlus22135298
Sequence
(Fasta)		MWLYLAAFVG LYYLLHWYRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD ARGLRVLAAC 60
LTEKGAEQLR GQTSDRLETV TLDVTKMESI AAATQWVKEH VGDRGLWGLV NNAGILTPIT 120
LCEWLNTEDS MNMLKVNLIG VIQVTLSMLP LVRRARGRIV NVSSILGRVA FFVGGYCVSK 180
YGVEAFSDIL RREIQHFGVK ISIVEPGYFR TGMTNMTQSL ERMKQSWKEA PKHIKETYGQ 240
QYFDALYNIM KEGLLNCSTN LNLVTDCMEH ALTSVHPRTR YSAGWDAKFF FIPLSYLPTS 300
LADYILTRSW PKPAQAV 318
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0325--Glycoprotein
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0492--Microsome
KW-0520--NAD
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0732--Signal
KW-0753--Steroid metabolism
Interpro

IPR002198--DH_sc/Rdtase_SDR
IPR002347--Glc/ribitol_DH
IPR016040--NAD(P)-bd_dom
IPR020904--Sc_DH/Rdtase_CS
PROSITE

PS00061--ADH_SHORT
Pfam

PF00106--adh_short
Gene Ontology

GO:0031901--C:early endosome membrane
GO:0005783--C:endoplasmic reticulum
GO:0005622--C:intracellular
GO:0003824--F:catalytic activity
GO:0009055--F:electron carrier activity
GO:0004303--F:estradiol 17-beta-dehydrogenase activity
GO:0016491--F:oxidoreductase activity
GO:0004745--F:retinol dehydrogenase activity
GO:0047035--F:testosterone dehydrogenase (NAD+) activity
GO:0006702--P:androgen biosynthetic process
GO:0006710--P:androgen catabolic process