| Tag |
Content |
| dbPAF ID |
dbPAF-0000734 |
| Uniprot Accession |
O14734; ACOT8_HUMAN; O15261; Q17RX4;
|
| Genbank Protein ID |
NP_005460.2;
|
| Genbank Nucleotide ID |
NM_005469.3;
|
| Protein Name |
Acyl-coenzyme A thioesterase 8 |
| Protein Synonyms/Alias |
|
| Gene Name |
ACOT8 |
| Gene Synonyms/Alias |
ACTEIII;PTE1;PTE2; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.Functional Description
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MSSPQAPEDG QGCGDRGDPP GDLRSVLVTT VLNLEPLDED LFRGRHYWVP AKRLFGGQIV 60
GQALVAAAKS VSEDVHVHSL HCYFVRAGDP KLPVLYQVER TRTGSSFSVR SVKAVQHGKP 120
IFICQASFQQ AQPSPMQHQF SMPTVPPPEE LLDCETLIDQ YLRDPNLQKR YPLALNRIAA 180
QEVPIEIKPV NPSPLSQLQR MEPKQMFWVR ARGYIGEGDM KMHCCVAAYI SDYAFLGTAL 240
LPHQWQHKVH FMVSLDHSMW FHAPFRADHW MLYECESPWA GGSRGLVHGR LWRQDGVLAV 300
TCAQEGVIRV KPQVSESKL
Fasta Sequence
>O14734|ACOT8|Homo sapiens(Human)
MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRQDGVLAVTCAQEGVIRVKPQVSESKL
|
| Keyword |
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-0378--Hydrolase
KW-0576--Peroxisome
KW-0962--Peroxisome biogenesis
KW-1185--Reference proteome
KW-0719--Serine esterase
|
| Interpro |
IPR003703--Acyl_CoA_thio
IPR029069--HotDog_dom
|
| PROSITE |
|
| Pfam |
|
| Gene Ontology |
GO:0005739--C:mitochondrion
GO:0005782--C:peroxisomal matrix
GO:0047617--F:acyl-CoA hydrolase activity
GO:0052689--F:carboxylic ester hydrolase activity
GO:0033882--F:choloyl-CoA hydrolase activity
GO:0052815--F:medium-chain acyl-CoA hydrolase activity
GO:0016290--F:palmitoyl-CoA hydrolase activity
GO:0005102--F:receptor binding
GO:0006637--P:acyl-CoA metabolic process
GO:0036109--P:alpha-linolenic acid metabolic process
GO:0006699--P:bile acid biosynthetic process
GO:0008206--P:bile acid metabolic process
GO:0044255--P:cellular lipid metabolic process
GO:0043649--P:dicarboxylic acid catabolic process
GO:0033540--P:fatty acid beta-oxidation using acyl-CoA oxidase
GO:0035338--P:long-chain fatty-acyl-CoA biosynthetic process
GO:0016559--P:peroxisome fission
GO:0044281--P:small molecule metabolic process
GO:0019432--P:triglyceride biosynthetic process
GO:0033559--P:unsaturated fatty acid metabolic process
GO:0016032--P:viral process
|
