dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000732
Uniprot Accession O14732; IMPA2_HUMAN; B0YJ29; Q9UJT3;
Genbank Protein ID NP_055029.1;
Genbank Nucleotide ID NM_014214.2;
Protein Name Inositol monophosphatase 2
Protein Synonyms/Alias
Gene Name IMPA2
Gene Synonyms/Alias IMP.18P;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
55TSAADLVTETDHLVEdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
160NGQRLRVSGETDLSKPhosphoSitePlus22135298
163RLRVSGETDLSKALVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
166VSGETDLSKALVLTEdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
182GPKRDPATLKLFLSNdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
Sequence
(Fasta)		MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL 60
VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI 120
GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP 180
ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR 240
EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK 289
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR020583--Inositol_monoP_metal-BS
IPR020552--Inositol_monoPase_Li-sen
IPR000760--Inositol_monophosphatase
IPR020550--Inositol_monophosphatase_CS
PROSITE

PS00629--IMP_1
PS00630--IMP_2
Pfam

PF00459--Inositol_P
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0008934--F:inositol monophosphate 1-phosphatase activity
GO:0052832--F:inositol monophosphate 3-phosphatase activity
GO:0052833--F:inositol monophosphate 4-phosphatase activity
GO:0000287--F:magnesium ion binding
GO:0042803--F:protein homodimerization activity
GO:0006021--P:inositol biosynthetic process
GO:0006020--P:inositol metabolic process
GO:0046855--P:inositol phosphate dephosphorylation
GO:0043647--P:inositol phosphate metabolic process
GO:0006796--P:phosphate-containing compound metabolic process
GO:0046854--P:phosphatidylinositol phosphorylation
GO:0007165--P:signal transduction
GO:0044281--P:small molecule metabolic process