dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000730
Uniprot Accession O14727; APAF_HUMAN; B2RMX8; O43297; Q7Z438; Q9BXZ6; Q9UBZ5; Q9UGN8; Q9UGN9; Q9UGP0; Q9UJ58; Q9UJ59; Q9UJ60; Q9UJ61; Q9UJ62; Q9UJ63; Q9UJ64; Q9UJ65; Q9UJ66; Q9UJ67; Q9UNC9;
Genbank Protein ID NP_001151.1; NP_037361.1; NP_863651.1; NP_863658.1; NP_863659.1;
Genbank Nucleotide ID NM_001160.2; NM_013229.2; NM_181861.1; NM_181868.1; NM_181869.1;
Protein Name Apoptotic protease-activating factor 1
Protein Synonyms/Alias
Gene Name APAF1
Gene Synonyms/Alias KIAA0413;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Phosphorylation Sites
 dbPAF PTMs: 19
PositionPeptidesSourceReferences ( PMIDs )
24EKDIKTSYIMDHMISPhosphoSitePlus22135298
31YIMDHMISDGFLTISPhosphoSitePlus22135298
48EKVRNEPTQQQRAAMPhosphoSitePlus22135298
204MKLQNLCTRLDQDESdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 21081558; 19366988;
238MLRKHPRSLLILDDVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 20068231; 21406692; 18988627;
248ILDDVWDSWVLKAFDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 20068231; 21406692; 18988627;
268LLTTRDKSVTDSVMGdbPTM 3.0;PhosphoSitePlus22246185; 16381945; 23193290; 22135298
272RDKSVTDSVMGPKYVPhosphoSitePlus22135298
278DSVMGPKYVVPVESSPhosphoSitePlus22135298
320IIKECKGSPLVVSLIPhosphoSitePlus22135298
357FKRIRKSSSYDYEALdbPTM 3.0;PhosphoSitePlus22246185; 16381945; 23193290; 22135298
369EALDEAMSISVEMLRPhosphoSitePlus22135298
371LDEAMSISVEMLREDPhosphoSitePlus22135298
382LREDIKDYYTDLSILPhosphoSitePlus22135298
383REDIKDYYTDLSILQPhosphoSitePlus22135298
901GSSFLTSSDDQTIRLPhosphoSitePlus22135298
905LTSSDDQTIRLWETKPhosphoSitePlus22135298
1103DATKFSSTSADKTAKPhosphoSitePlus22135298
1108SSTSADKTAKIWSFDPhosphoSitePlus22135298
Sequence
(Fasta)		MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGFLTISEE EKVRNEPTQQ QRAAMLIKMI 60
LKKDNDSYVS FYNALLHEGY KDLAALLHDG IPVVSSSSGK DSVSGITSYV RTVLCEGGVP 120
QRPVVFVTRK KLVNAIQQKL SKLKGEPGWV TIHGMAGCGK SVLAAEAVRD HSLLEGCFPG 180
GVHWVSVGKQ DKSGLLMKLQ NLCTRLDQDE SFSQRLPLNI EEAKDRLRIL MLRKHPRSLL 240
ILDDVWDSWV LKAFDSQCQI LLTTRDKSVT DSVMGPKYVV PVESSLGKEK GLEILSLFVN 300
MKKADLPEQA HSIIKECKGS PLVVSLIGAL LRDFPNRWEY YLKQLQNKQF KRIRKSSSYD 360
YEALDEAMSI SVEMLREDIK DYYTDLSILQ KDVKVPTKVL CILWDMETEE VEDILQEFVN 420
KSLLFCDRNG KSFRYYLHDL QVDFLTEKNC SQLQDLHKKI ITQFQRYHQP HTLSPDQEDC 480
MYWYNFLAYH MASAKMHKEL CALMFSLDWI KAKTELVGPA HLIHEFVEYR HILDEKDCAV 540
SENFQEFLSL NGHLLGRQPF PNIVQLGLCE PETSEVYQQA KLQAKQEVDN GMLYLEWINK 600
KNITNLSRLV VRPHTDAVYH ACFSEDGQRI ASCGADKTLQ VFKAETGEKL LEIKAHEDEV 660
LCCAFSTDDR FIATCSVDKK VKIWNSMTGE LVHTYDEHSE QVNCCHFTNS SHHLLLATGS 720
SDCFLKLWDL NQKECRNTMF GHTNSVNHCR FSPDDKLLAS CSADGTLKLW DATSANERKS 780
INVKQFFLNL EDPQEDMEVI VKCCSWSADG ARIMVAAKNK IFLFDIHTSG LLGEIHTGHH 840
STIQYCDFSP QNHLAVVALS QYCVELWNTD SRSKVADCRG HLSWVHGVMF SPDGSSFLTS 900
SDDQTIRLWE TKKVCKNSAV MLKQEVDVVF QENEVMVLAV DHIRRLQLIN GRTGQIDYLT 960
EAQVSCCCLS PHLQYIAFGD ENGAIEILEL VNNRIFQSRF QHKKTVWHIQ FTADEKTLIS 1020
SSDDAEIQVW NWQLDKCIFL RGHQETVKDF RLLKNSRLLS WSFDGTVKVW NIITGNKEKD 1080
FVCHQGTVLS CDISHDATKF SSTSADKTAK IWSFDLLLPL HELRGHNGCV RCSAFSVDST 1140
LLATGDDNGE IRIWNVSNGE LLHLCAPLSE EGAATHGGWV TDLCFSPDGK MLISAGGYIK 1200
WWNVVTGESS QTFYTNGTNL KKIHVSPDFK TYVTVDNLGI LYILQTLE 1249
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0106--Calcium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40
Gene Ontology

GO:0043293--C:apoptosome
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000166--F:nucleotide binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0007568--P:aging
GO:0006915--P:apoptotic process
GO:0010659--P:cardiac muscle cell apoptotic process
GO:0030154--P:cell differentiation
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0030900--P:forebrain development
GO:0034349--P:glial cell apoptotic process
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0007399--P:nervous system development
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:0043065--P:positive regulation of apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0012501--P:programmed cell death
GO:0051260--P:protein homooligomerization
GO:1902510--P:regulation of apoptotic DNA fragmentation
GO:0042981--P:regulation of apoptotic process
GO:0072432--P:response to G1 DNA damage checkpoint signaling
GO:0001666--P:response to hypoxia
GO:0007584--P:response to nutrient