dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000729
Uniprot Accession O14717; TRDMT_HUMAN; B0YJ02; B0YJ03; B0YJ07; B0YJ08; O43669; Q86WW6;
Genbank Protein ID NP_004403.1; XP_005252432.1;
Genbank Nucleotide ID NM_004412.5; XM_005252375.3;
Protein Name tRNA (cytosine(38)-C(5))-methyltransferase
Protein Synonyms/Alias DNA (cytosine-5)-methyltransferase-like protein 2;Dnmt2;DNA methyltransferase homolog HsaIIP;DNA MTase homolog HsaIIP;M.HsaIIP;PuMet;
Gene Name TRDMT1
Gene Synonyms/Alias DNMT2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
153EFLLSPTSLGIPNSRPhosphoSitePlus22135298
Sequence
(Fasta)		MEPLRVLELY SGVGGMHHAL RESCIPAQVV AAIDVNTVAN EVYKYNFPHT QLLAKTIEGI 60
TLEEFDRLSF DMILMSPPCQ PFTRIGRQGD MTDSRTNSFL HILDILPRLQ KLPKYILLEN 120
VKGFEVSSTR DLLIQTIENC GFQYQEFLLS PTSLGIPNSR LRYFLIAKLQ SEPLPFQAPG 180
QVLMEFPKIE SVHPQKYAMD VENKIQEKNV EPNISFDGSI QCSGKDAILF KLETAEEIHR 240
KNQQDSDLSV KMLKDFLEDD TDVNQYLLPP KSLLRYALLL DIVQPTCRRS VCFTKGYGSY 300
IEGTGSVLQT AEDVQVENIY KSLTNLSQEE QITKLLILKL RYFTPKEIAN LLGFPPEFGF 360
PEKITVKQRY RLLGNSLNVH VVAKLIKILY E 392
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0819--tRNA processing
Interpro

IPR001525--C5_MeTfrase
IPR031303--C5_meth_CS
IPR029063--SAM-dependent_MTases
PROSITE

PS00095--C5_MTASE_2
PS51679--SAM_MT_C5
Pfam

PF00145--DNA_methylase
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0003886--F:DNA (cytosine-5-)-methyltransferase activity
GO:0003723--F:RNA binding
GO:0008175--F:tRNA methyltransferase activity
GO:0090116--P:C-5 methylation of cytosine
GO:0010467--P:gene expression
GO:0001975--P:response to amphetamine
GO:0030488--P:tRNA methylation
GO:0006400--P:tRNA modification
GO:0008033--P:tRNA processing