Tag |
Content |
dbPAF ID |
dbPAF-0000727 |
Uniprot Accession |
O14713; ITBP1_HUMAN; D6W4Y9; O14714; Q53RS0; |
Genbank Protein ID |
NP_004754.1; NP_071729.1; XP_005246240.1; XP_005246241.1; XP_005246242.1; XP_005246243.1; XP_005246244.1; XP_005246246.1; XP_006711966.1; XP_011508718.1; |
Genbank Nucleotide ID |
NM_004763.3; NM_022334.3; XM_005246183.3; XM_005246184.3; XM_005246185.3; XM_005246186.3; XM_005246187.3; XM_005246189.3; XM_006711903.2; XM_011510416.1; |
Protein Name |
Integrin beta-1-binding protein 1 |
Protein Synonyms/Alias |
Integrin cytoplasmic domain-associated protein 1;ICAP-1; |
Gene Name |
ITGB1BP1 |
Gene Synonyms/Alias |
ICAP1; |
Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.Functional Description
Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.
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Phosphorylation Sites
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dbPAF PTMs: 21 (View all) |
Sequence (Fasta) | MFRKGKKRHS SSSSQSSEIS TKSKSVDSSL GGLSRSSTVA SLDTDSTKSS GQSNNNSDTC 60 AEFRIKYVGA IEKLKLSEGK GLEGPLDLIN YIDVAQQDGK LPFVPPEEEF IMGVSKYGIK 120 VSTSDQYDVL HRHALYLIIR MVCYDDGLGA GKSLLALKTT DASNEEYSLW VYQCNSLEQA 180 QAICKVLSTA FDSVLTSEKP
201Fasta Sequence
>O14713|ITGB1BP1|Homo sapiens(Human) MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDTDSTKSSGQSNNNSDTCAEFRIKYVGAIEKLKLSEGKGLEGPLDLINYIDVAQQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQYDVLHRHALYLIIRMVCYDDGLGAGKSLLALKTTDASNEEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSEKP
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Keyword |
KW-0002--3D-structure KW-0025--Alternative splicing KW-0037--Angiogenesis KW-0091--Biomineralization KW-0130--Cell adhesion KW-1003--Cell membrane KW-0966--Cell projection KW-0181--Complete proteome KW-0963--Cytoplasm KW-0206--Cytoskeleton KW-0221--Differentiation KW-0472--Membrane KW-0497--Mitogen KW-0914--Notch signaling pathway KW-0539--Nucleus KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0804--Transcription KW-0805--Transcription regulation
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Interpro |
IPR019517--Integrin-bd_ICAP-1 IPR011993--PH/PTB_dom IPR006020--PTB/PI_dom
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PROSITE |
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Pfam |
PF10480--ICAP-1_inte_bdg
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Gene Ontology |
GO:0071944--C:cell periphery GO:0005737--C:cytoplasm GO:0005856--C:cytoskeleton GO:0005829--C:cytosol GO:0070062--C:extracellular exosome GO:0030027--C:lamellipodium GO:0016020--C:membrane GO:0005634--C:nucleus GO:0048471--C:perinuclear region of cytoplasm GO:0005886--C:plasma membrane GO:0001726--C:ruffle GO:0005092--F:GDP-dissociation inhibitor activity GO:0005178--F:integrin binding GO:0032403--F:protein complex binding GO:0008565--F:protein transporter activity GO:0032148--P:activation of protein kinase B activity GO:0031214--P:biomineral tissue development GO:0002043--P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0030154--P:cell differentiation GO:0016477--P:cell migration GO:0007160--P:cell-matrix adhesion GO:0044344--P:cellular response to fibroblast growth factor stimulus GO:0035924--P:cellular response to vascular endothelial growth factor stimulus GO:0033622--P:integrin activation GO:0007229--P:integrin-mediated signaling pathway GO:0035556--P:intracellular signal transduction GO:0051451--P:myoblast migration GO:0006933--P:negative regulation of cell adhesion involved in substrate-bound cell migration GO:0090051--P:negative regulation of cell migration involved in sprouting angiogenesis GO:0008285--P:negative regulation of cell proliferation GO:0070373--P:negative regulation of ERK1 and ERK2 cascade GO:0010764--P:negative regulation of fibroblast migration GO:0051895--P:negative regulation of focal adhesion assembly GO:0032091--P:negative regulation of protein binding GO:0006469--P:negative regulation of protein kinase activity GO:0090315--P:negative regulation of protein targeting to membrane GO:1900025--P:negative regulation of substrate adhesion-dependent cell spreading GO:0007219--P:Notch signaling pathway GO:0051781--P:positive regulation of cell division GO:0008284--P:positive regulation of cell proliferation GO:0010595--P:positive regulation of endothelial cell migration GO:0051894--P:positive regulation of focal adhesion assembly GO:0045747--P:positive regulation of Notch signaling pathway GO:0051897--P:positive regulation of protein kinase B signaling GO:0090314--P:positive regulation of protein targeting to membrane GO:0051496--P:positive regulation of stress fiber assembly GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0015031--P:protein transport GO:0043113--P:receptor clustering GO:0050880--P:regulation of blood vessel size GO:0033628--P:regulation of cell adhesion mediated by integrin GO:0043087--P:regulation of GTPase activity GO:2001044--P:regulation of integrin-mediated signaling pathway GO:0006351--P:transcription, DNA-templated GO:0035148--P:tube formation
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